Crude drug sample data base

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Crude drug name

Market name生吉草根
Formal nameカノコソウ，吉草根
Japanese nameカノコソウ: かのこそう, Kanokosō, 吉草根: きっそうこん, Kissōkon
Latin nameValerianae fauriei Radix (JP)
English nameJapanese Valerian (JP)
Original plant nameValeriana fauriei Briquet (f. yezoensis Hara), Kanokoso (Ezokanokoso)
Family nameValerianaceae
Used partClassificationPlant origin
Sub classification root + rhizome
Collection informationJapan, Osaka Pref., Nippon Funmatsu Yakuhin Co.,Ltd.
Collection date1970/05/00
TMPW No.1118

The capital city, provincial capital city or the representative　　
location of its administrative area is indicated.　　
Production area information
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34.6937378
135.50216509999996
Collection information
Japan,Osaka Pref.
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Scientific information data base

Common nameカノコソウ, 吉草根, Kanokosō, Kissōkon, Valerianae Fauriei Radix (JP18), Japanese Valerian (JP18)
Synonyms纈草根
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Original plant nameValeriana fauriei Briquet1, (Kanokoso1, Ezokanokosō (Hokkaikissō))
original plant image
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Family nameValerianaceae
Used partroot and rhizome
Quality for selectionGood Kanokosou has lots of palp-like roots. It is reddish brown. (TN)
Official compendiumJP XVIII
Clinical applicationAs an tranquilizer, antispasmodic and for expelling wind-cold, kanokosou is applied for hysteria and palpitation of the heart as fluid extract (up to 6g a day) or tincture (up to 1.5g a day). It is an ingredient of domestic medicine.
Medical systemTraditional Chinese medicine
Chemical constituentMonoterpenoids
V. fauriei 精油 [volatile oil] 1～8% (*C1, C2):
Cineole, Camphene, Limonene, p-Cymene, Borneol, alpha-Pinene, beta-Pinene, Terpineol, Bornyl isovalerate（主成分約 [major constituent about] 90%）, Bornyl acetate
V. fauriei Briq. f. yezoensis Hara (*C1):
イリドイド配糖体/iridoid glycoside：
Kanokoside A, Kanokoside B, Kanokoside C, Kanokoside D

Sesquiterpenoids
V. fauriei 精油 [volatile oil] 1～8% (*C1):
alpha-Kessyl alcohol, alpha-Kessyl glycol, alpha-Kessylacetate, Kessoglycol, Kessazulene (Guaiazulene), Kessane, Kessanol, 8-epi-Kessanol, Valeranone(= Jatamansone), Kanokonol, Fauronyl acetate, Kanokonyl acetate, Cryptofauronol

Chemical structure




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Pharmacological effectSedative（kessoglycol diacetate, kessoglycol 2-acetate, kessoglycol 8-acetate)，antidepressant (alpha-kessyl alcohol, kessanol, cyclokessyl acetate)，suppression of stress-induced ulcer．
DNA sequenceL13934, AJ236003 ; Traditioal Medical & Parmaceutical Database.
DiseaseHysteria, Palpitation
Formulation
Related drugsValerianae Rhizoma, Indian Valeriana (see "Remarks")
ReferencesJP18: The 18th edition of the Japanese Pharmacopoeia.
C1)The Encyclopedia of Wakan-Yaku with Color Pictures Vol. I, pp 132-133.
C2) Outline of Pharmacognosy, a Textbook，p223.
C3) Nat. Med., 55, 225, 231(2001).
RemarksValerianae Rhizoma: Root or rhizome of Valeriana officinale L. of family Valerianaceae (Jap. name: Seiyokanokoso). Indian Valeriana: Root or rhizome of V. wallichii DC. and others. "Kissokon" is the substitute for European Valerianae, which has been listed in The Japanese Pharmacopoeia since its first edition (1886). The plants of genus Valeriana are not used in China. A Japanese crude drug "Kanokoso", which circulates in the Japanese market, originates from Hokkaikisso (a kind of "Ezokanokoso"). "Hokkaikisso" consists of two varieties, Botan and Tako. There are considerable disparity in medicinal properties between the lineages. (C3)
Last renewal date2021/09/27
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