Crude drug sample data base

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Crude drug name

Market name炮附子
Formal name附子
Japanese nameぶし, Bushi
Vernacular nameFuzi
Latin nameAconiti Radix Processa (JP), Aconiti Lateralis Radix Praeparata (CP) Aconiti Tuber
English nameProcessed Aconite Root (JP), Prepared Common Monkshood Daughter Root (CP), Aconite, Common Monkshood Daughter Root
Original plant nameAconitum carmichaeli Debx., Hanatorikabuto (Karatorikabuto)
Family nameRanunculaceae
Used partClassificationPlant origin
Sub classification tuber
Collection informationJapan, Osaka Pref., Tochimoto Tenkaido Co., Ltd.
Collection date1972/04/13
TMPW No.162

The capital city, provincial capital city or the representative  
location of its administrative area is indicated.  
Production area information
Collection information
Japan,Osaka Pref.

Scientific information data base

Common name附子, Fuzi, Aconiti Radix Processa (JP18), Aconiti Lateralis Radix Praeparata (CP2020), Processed Aconite Root (JP18), Prepared Common Monkshood Daughter Root (CP2020)
Synonyms加工附子, 塩附子, 炮附子, 黒附片, 白河附子
crude drug image
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Original plant nameCN production: Aconitum carmichaeli Debeaux1, JP production: Aconitum japonicum Thunberg2, (Hanatorikabuto1, Okutorikabuto2)
original plant image
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Family nameRanunculaceae
Used parttuber (lateral root), harvested from late June to early August.
Quality for selectionThe best Fuzi is the size of hen's egg. (NI)
Official compendiumJP XVIII, CP (2020 ed.)
Clinical applicationAs a tonic, diuretic, cardiotonic and painkiller, Fuzi is applied for metabolic dysfunction, joint paralysis and pain of limbs and disease due to relaxation of internal organs such as invalid's stomachache, diarrhea and pollution.
Medical systemTraditional Chinese medicine
Drug effect in
traditional medicine
Drugs for dispelling internal cold
Beneficial effect[Property and Flavor] Highly hot; pungent and sweet; toxic.
[Meridian Tropism] Heart, kidney and spleen meridians.
[Actions] To restore yang, induce resuscitation, tonify fire and assist yang, dissipate cold and relieve pain.
[Indications] Yang collapse, coldness of limbs and faint pulse, deficiency of heart yang with chest impediment and heart pain, deficiency cold vomiting and diarrhea, cold pain in the epigastrium and abdomen, debilitation of kidney yang, impotence and uterine coldness, yin-cold edema, external contraction with yang deficiency, and cold-dampness arthralgia.
Chemical constituentAlkaloids
A. carmichaeli (*C1):
Aconitine, Hypaconitine, Mesaconitine, Carmichaeline, Talatisamine, Coryneine chloride
A. japonicum (*C1):
Aconitine, Mesaconitine, Hypaconitine, Hygenamine
Aconitum spp. (*C2):
Aconitine系 (type):Aconitine, Hypaconitine, Mesaconitine, Jesaconitine, Neopelline, Atisin系 (type):Atisine, Kobusine, Pseudokobusine, Telatisine, Songorine, Atidine, Napelline, Heteratisine, Hypognavine, Ignavine, 強心成分 (Cardiotonic compounds):Hygenamine, Coryneine, Yokonoside, etc.
A. ferox (*C1):
A. heterophyllum(*C1):
Atidine, Atisine, Hetisine, Heteratisine, Benzoylheteratisine
A. napellus (*C1):
Songorine, Napelline, Hypaconitine, Mesaconitine, Neopelline, Neoline, Aconine, Benzoylaconine, Aconitine, Napellonine

Chemical structure

Pharmacological effectSedative,suppression of stress ulcer (extract).Sedative,hypotensive,induction of arrythmia (aconitine),cardiotonic (hygenamine, coryneine).Analgesic and antiinflammatory (mesaconitine).
DNA sequenceAB020369, AB020370, AB020371, AB020372, AB020373, AB020374; Traditioal Medical & Parmaceutical Database.
Classical reference
(Chinese Herbal Classic "Zhenglei bencao")
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DiseasePallor of the face, Cyanosis, Coldness of limbs, Weak pulse, Spontaneous sweating, Heaviness and powerlessness in lumber and knee, Frequent urination, Sexual problem, Muddy and watery stool, Lower back pain, Oliguria, Full stomach, Swelling and pain of joint, Numbness, Chill
FormulationAkyobushito, Uzushakusekisigan, Unpito, Kaikyushokushoto, Kakkonkaryojutsubuto, Kankyobushito, Kanzobushito, Kinkohojutsubuto, Keikyososooshinbuto, Keishikajutsubuto, Keishikaryojutsubuto, Keishikyoshakuyakukamaobushisaishinto, Keishishakuyakuchimoto, Keishinieppiittokaryojutsubu, Keishibushito, Kobokuto, Goshajinkigan, Sanshoin, Shigyakuto, Shigyakukaninjinto, Shakukan'oshinbuto, Shakuyakukanzobushito, Shakuyakukanzobushidaioto, Shokanto, Shozokumeito, Jokinritsuansan, Shimbuto, Seikanto, Sogento, Daiobushito, Daisangoshichisan, Daitokato, Daibofuto, Danrito, Chikuyoto, Chokobukuryoto, Choburichuto, Tsumyakushigyakuto, Hachimigangoninjinto, Hachimijiogan, Hanbikokantan, Byakujutsubushito, Bukuryoshigyakuto, Hojinto, Hontonto, Maokaryojutsubuto, Maobushikanzoto, Maobushisaishinto, Yokuibushihaishosan, Rikakuto, Rokumotsubushito
Related drugswutou, tianxiong
ReferencesJP18: The 18th edition of the Japanese Pharmacopoeia.
CP2020: Pharmacopoeia of the People's Republic of China 2020 edi.
C1) The Encyclopedia of Wakan-Yaku with Color Pictures Vol. I, pp 91-97.
C2) Outline of Pharmacognosy, a Textbook, pp 304-305.
RemarksThe Pharmacopoeia of the People's Republic of China defines "Fuzi (附子)" as the processed tuber (lateral roots) of Aconitum carmichaeli. The processed aconite root, which is compressed and heated, is used for many kinds of Kampo drug products. Since aconitum alkaloids have strong toxicity, there are many processes to reduce it. It is called "Yanfuzi (塩附子)," "Paofuzi (炮附子)," "Heifupian (黒附片)" or "Baifupian (白附片)" depending on each process.
- Chinese "Yanfuzi (塩附子)", the tuber of Aconitum carmichaeli, is half dried after rinsed in the solution of salt water and bittern.
- "Paofuzi (炮附子)" is the dried "Yanfuzi (塩附子)" after being peeled and divided lengthwise.
- Both "Heifupian (黒附片)" and "Refupian (熟附片)" are made as follows : rinse roots in bittern, divide them lengthwise, stain with dye stuff, dry after steaming.
- Though "Baifupian (白附片)" is the similar product to "Heifupian (黒附片)", it is barked and smoked by sulfur untill it becomes white at its final process.

The Japanese "Shirakawa-bushi," the tuber of Aconitum japonicum, is made as follows : rinse it in salt water, coat with lime and dry.
It is mentioned in the Japanese Pharmacopoeia that there are three ways in processing the aconite tuber.
1: Autoclaving.
2: Heating or autoclaving after rinsing in salt or rock salt solution.
3: Treating with calcium hydroxide after rinsing in salt solution.
Last renewal date2021/09/27