Crude drug sample data base
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Crude drug name | Market name | 巴豆 |
|---|---|---|
| Formal name | 巴豆 | |
| Japanese name | はず, Hazu | |
| Latin name | Crotonis Fructus (CP), Crotonis Semen (Tiglium) | |
| English name | Croton Fruit (CP), Croton Seed | |
| Original plant name | Croton tiglium L., (Hazu) | |
| Family name | Euphorbiaceae | |
| Used part | Classification | Plant origin | Sub classification | seed |
| TMPW No. | 1941 | |
Scientific information data base
| Common name | 巴豆, Badou, Crotonis Fructus (CP2020), Crotonis Semen, Croton Fruit (CP2020), Croton Seed | ||||
|---|---|---|---|---|---|
| crude drug image |
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| Original plant name | Croton tiglium Linn., (Hazu) | ||||
| Family name | Euphorbiaceae | ||||
| Used part | seed | ||||
| Quality for selection | Good one is heavy, oily, fresh, and pungent. The one which floats on the water is inferior. (NI) | ||||
| Official compendium | CP (2020 ed.) | ||||
| Clinical application | A drastic purgative, emetic. Badou is used as pills or emulsion. Great care should be taken to use it because of its drastic physiologic activity. The ointment is made from its oil and given to prevent frostbite as a skin irritant. | ||||
| Medical system | Traditional Chinese medicine | ||||
| Drug effect in traditional medicine | Traditional classification | Purgatives | |||
| Beneficial effect | [Property and Flavor] Hot; pungent; highly toxic. [Meridian Tropism] Stomach and large intestine meridians. [Actions] Topically to heal wounds. [Indications] Serious sore, scabies and tinea, verruca and nevus. | ||||
| Chemical constituent | Fatty acids related compounds (*C1): Croton resin, Oleic acid, Linolic acid, Arachic acid, Stearic acid, Palmitic acid, Lauric acidのglycerides, Tiglic acid, Crotonic acid Diterpenoids (*C1): Phorbolを基礎アルコールとしたtiglic, lactic, acetic, formic acidsのエステル (*C2, C3): 12-O-Acetylphorbol 13-decanoate 12-O-Decanoylphorbol 13-(2-methylbutyrate) 12-O-Tetradecanoylphorbol 13-acetate (TPA), 他9種類/ and other 9 types Other nitrogen containing compounds (*C1): Crotin, Croton-albumin | ||||
| Chemical structure | 
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| Pharmacological effect | Drastic purgation (phorbol ester), inhibition of cytopathy due to HIV virus, stimulation of protein kinase C (carcinogenic stimulation) (C2,C3). | ||||
| Classical reference (Chinese Herbal Classic "Zhenglei bencao") |  ※Click this image to see the actual image | ||||
| Disease | Abdominal pain, Full stomach, Constipation, Coldness of limbs, Pain due to abdominal coldness, Disturbance of consciousness, Ascites, Oliguria, Feeling of pressure in the chest, Hyperhidrosis, Nasal congestion, Pyogenic dermatosis | ||||
| Formulation | Kikyohakusan | ||||
| References | CP2020: Pharmacopoeia of the People's Republic of China 2020 edi. C1)The Encyclopedia of Wakan-Yaku with Color Pictures Vol. I, pp 194-195. C2) Chem. Pharm. Bull., 47, 1346-1347 (1999). [PMID: 10517016] C3) Phytochem., 53, 457-464 (2000). [PMID: 10731023] | ||||
| Remarks | Badou (巴豆) is generally imported in the form of a fruit. The Pharmacopoeia of the People's Republic of China defines mature fruit of Croton tiglium L. (Jap. name: Hazu) as Badou. Its medicinal properties are drastic and intestinal hemorrhage can be a side effect. Recently, it was found that the component of the methanol extract from Badou inhibits cytopathy caused by the HIV-1 virus. (C2,C3) | ||||
| Last renewal date | 2021/09/28 | ||||
