Crude drug sample data base

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Crude drug name

Market name牡丹皮
Formal name牡丹皮
Japanese nameぼたんぴ, Botampi
Vernacular nameMokdampi
Latin nameMoutan Cortex (JP), (CP)
English nameMoutan Bark (JP), Tree Peony Bark (CP)
Original plant namePaeonia suffruticosa Andrews (= Paeonia moutan Sims.), (Botan)
Family namePaeoniaceae
Used partClassificationPlant origin
Sub classification root bark
Production area informationRepublic of Korea
TMPW No.2488

Scientific information data base

Common name牡丹皮, Mudanpi, Moutan Cortex (JP18, CP2020), Moutan Bark (JP18), Tree Peony Bark (CP2020)
Synonyms鳳凰牡丹皮
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Original plant namePaeonia suffruticosa Andrews (= Paeonia moutan Sims), (Botan)
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Family namePaeoniaceae
Used partroot bark
Quality for selectionGood Mudanpi has radial thickness without xylem. There are white powders on the cross section. It has strong aroma. (TN)
Official compendiumJP XVIII, CP (2020 ed.)
Clinical applicationAs a tranquilizer, painkiller, for removing blood stasis and draining pus, mudanpi is applied for hematogenous disorder (blood circulation stasis) such as headache, abdominal pain, gynecologic disease, menstrual disorder and dysmenorrhea.
Medical systemTraditional Chinese medicine
Drug effect in
traditional medicine
Traditional
classification
Drugs for eliminating heat from blood
Beneficial effect[Property and Flavor] Mild cold; bitter and pungent.
[Meridian Tropism] Heart, liver and kidney.
[Actions] To clear heat and cool the blood, activate blood to resolve stasis.
[Indications] Heat entering nutrient-blood aspects, macula and papule caused by warm toxin, hematemesis, epistaxis, fever at night and cool in the morning, steaming bone fever without sweating, amenorrhea and dysmenorrhea, pain caused by traumatic injuries, swelling abscess, sore and skin infections.
Chemical constituentMonoterpenoids
(*C1):
Paeoniflorin, Oxypaeoniflorin, Benzoylpaeoniflorin, Benzoyloxypaeoniflorin
(*C2):
Galloyl-paeoniflorin, Galloyl-oxypaeoniflorin

Sterols
(*C1):
Campesterol, beta-Sitosterol

Tannins
(*C2):
Tetragalloylglucose, Pentagalloylglucose

Other aromatic derivatives
(*C1):
Paeonol, Paeonolide, Paeonoside, Benzoic acid
(*C2):
Suffruticoside A, Suffruticoside B, Suffruticoside C, Suffruticoside D, Suffruticoside E

Chemical structure



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Pharmacological effectAntiinflammatory (methanol extract),analgesic,antibacterial (E. coli, S. aureus),antiinflammatory,suppression of gastric juice secretion (paeonol).
DNA sequenceTraditioal Medical & Parmaceutical Database.
Classical reference
(Chinese Herbal Classic "Zhenglei bencao")
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DiseaseFever, Internal bleeding, Hematemesis, Nasal hemorrhage, Amenorrhea, Menorrhalgia, Intra-abdominal tumor, Swelling and pain due to contusion, Appendicitis, Pyogenic dermatosis, Headache, Red eye, Thirst, Irregular menstruation
FormulationUnkeito, Kashininto, Katsuketsusan'oto, Kamishoyosan, Kamishoyosangoshimotsuto, Kyukichoketsuin, Keishibukuryogan, Goshitsusan, Goshajinkigan, Saikakujioto, Saikosokanto, Shichikensan, Shaito, Seinetsuhoketsuto, Sesshoin, Daiobotampito, Choyoto, Choyotokashakuyaku, Tojinto, Toryuto, Hachimigangoninjinto, Hachimijiogan, Hachimisenkiho, Hokoeito, Botanpisan, Yokuininto, Rokumijiogan, Kogikujiogan
ReferencesJP18: The 18th edition of the Japanese Pharmacopoeia.
CP2020: Pharmacopoeia of the People's Republic of China 2020 edi.
C1) The Encyclopedia of Wakan-Yaku with Color Pictures Vol. II, pp 132-133.
C2) The Journal of Traditional Sino-Japanese Medicine 15(1), 95-103(1994).
RemarksThere are many varieties of peony. The origin of Mudanpi is complicated and the composition of the chemical component varies slightly according to the species. The Mudanpi without core, which is produced in Nara Prefecture, is good quality. The best product in China is produced at Tonglingfenghuangshan in Anhui Prov. which is called "Fenghuangmudanpi" or "Fengdanpi". The Japanese Pharmacopoeia defines Mudanpi as the one which contains not less than 1.0%(JP17) but 0.9%(JP18) of Paeonol.
Last renewal date2021/09/27