Crude drug sample data base

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Crude drug name

Market name細辛
Formal name細辛
Japanese nameさいしん, Saishin
Vernacular nameXixin
Latin nameAsari Herba cum Radice
English nameAsiasarum Root (JP), Manchurian Wildginger Root (CP)
Original plant nameAsiasarum sieboldii F. Maekawa1 or Asiasarum heterotropoides F. Maekawa var. mandshuricum F. Maekawa2, Asiasarum heterotropoides F. Maekawa var. seoulens F. Maekawa3, (Usubasaishin1, Keirinsaishin2, Usugesaishin3)
Family nameAristolochiaceae
Used partClassificationPlant origin
Sub classification root
Production area informationPeople's Republic of China, Liaoning Prov.
Collection informationJapan, Osaka Pref., Tochimoto Tenkaido Co., Ltd.
Collection date2008/10/10
CollectorKatsuko Komatsu
TMPW No.25904

The capital city, provincial capital city or the representative  
location of its administrative area is indicated.  
41.805699
123.43147199999999
Production area information
People's Republic of China,Liaoning Prov.
https://ethmed.toyama-wakan.net/img/pin_san.png
34.6937378
135.50216509999996
Collection information
Japan,Osaka Pref.
https://ethmed.toyama-wakan.net/img/pin_nyu.png

Scientific information data base

Common name細辛, Xixin, Asiasari Radix (JP18), Asari Radix et Rhizoma (CP2020) , Asiasarum Root (JP18), Manchurian Wildginger Root (CP2020)
Synonyms華細辛, 北細辛, 漢城細辛, 遼細辛
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Original plant nameAsiasarum heterotropoides F. Maekawa var. mandshuricum F. Maekawa1, Asiasarum sieboldii F. Maekawa2, (Keirinsaishin1, Usubasaishin2)
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Family nameAristolochiaceae
Used partroot & rhizome
Quality for selectionGood Xixin has strong odour and pungency. (TN)
Official compendiumJP XVIII, CP (2020 ed.)
Clinical applicationAs an antitussive, expectorant, tranquilizer, painkiller and metabolic promoter, xixin is applied for cough with thin sputum due to chronic bronchitis and bronchiectasis, frequent cough with headache, chest pain and a feeling of fullness in the chest.
Medical systemTraditional Chinese medicine
Drug effect in
traditional medicine
Traditional
classification
Drugs for dispelling internal cold
Beneficial effect[Property and Flavor] Warm; pungent.
[Meridian Tropism] Heart, lung and kidney meridians.
[Actions] To release the exterior, dissipate cold, dispel wind,relieve pain, open the orifices, warm the lung and resolve fluid retention.
[Indications] Common cold caused by wind-cold, headache, toothache, stuffy and runny nose, allergic rhinitis, sinusitis, painful impediment caused by wind-dampness, wheezing and cough caused by phlegm-fluid retention.
Chemical constituentFatty acids
A. heterotropoides var. seoulense (*C1):
Parmitic acid

Monoterpenoids
A. sieboldii (*C1):
Eucarvone, Limonene, 1,8-Cineole, 3-Caren-2-on-5-ol, 2-Epoxycaran-2-on-3-ol
A. heterotropoides var. seoulense (*C1):
l-beta-Pinene, Eucarvone

Phenylpropanoids
A. sieboldii (*C1):
Methyleugenol, Elemicin
A. heterotropoides var. seoulense (*C1):
Methyleugenol, Safrole, Kakuol
A. heterotropoides var. mandshuricum (*C1):
Kakuol

Lignans & Neolignans
A. sieboldii (*C1):
l-Asarinin
A. heterotropoides var. seoulense (*C1):
l-Sesamin
(*C2):
Asatone

Isoquinoline alkaloids
A. heterotropoides var. mandshuricum (*C1):
Higenamine

Capsaicins
A. heterotropoides var. mandshuricum (*C1):
Pellitorine, 2E,4E,8Z,10E,-N-Isobutyl-2,4,8,10-dodecatetraenamide, 2E,4E,8Z,10Z-N-Isobutyl-2,4,8,10-dodecatetraenamide

Chemical structure



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Pharmacological effectAntiinflammatory, antihistaminic (water extract), sedative, antipyretic, analgesic (essential oil).
DNA sequenceAF061499, AF061500, AF061501, AF061502; Traditioal Medical & Parmaceutical Database.
Classical reference
(Chinese Herbal Classic "Zhenglei bencao")
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DiseaseCough, Chronic bronchitis, Bronchiectasis, Headache, Nasal obstruction, Sinusitis, Dyspnea, Somatic pain, Swelling and pain of joint, Toothache, Chill, Common cold
FormulationKagenshahakusan, Kufushokutsuto, Keikyososooshinbuto, Keishikyoshakuyakukamaobushisaishinto, Kobokumaoto, San'oto, Shakukan'oshinbuto, Shadojindaioto, Shoseiryuto, Shoseiryukasekkoto, Shoseiryugomakyokansekito, Shin'isan, Seijokentsuto, Sekiganryo (keihi), Sekiganryo (hange), Daiobushito, Daisangoshichisan, Tokishigyakuto, Tokishigyakukagoshuyushokyoto, Dokkatsukiseito, Maobushisaishinto, Meiroin, Yakammaoto, Rikkosan, Ryokankyomishingeto, Ryokankyomishingeninto, Ryokankyomishingeninoto, Ryokangomikyoshinto
Related drugsTuxixin (Duheng) [see "Remarks"]
ReferencesJP18: The 18th edition of the Japanese Pharmacopoeia.
CP2020: Pharmacopoeia of the People's Republic of China 2020 edi.
C1) The Encyclopedia of Wakan-Yaku with Color Pictures Vol. II, pp 14-15.
C2) Outline of Pharmacognosy, a Textbook, pp 298-299.
Remarks- Both Chinese Xixin (Asiasarum heterotropoides var. mandshuricum, Jap. name: Keirinsaishin and others) and the Xixin of Korean peninsula (A. heterotropoides var. seoulense F. Maekawa, Jap. name: Usugesaishin) are made of the whole plant including roots.
- The Japanese Pharmacopoeia defines it as the root & rhizome of Asiasarum heterotropoides var. mandshuricum (Jap. name: Keirinsaishin) or A. sieboldii (Jap. name: Usubasaishin). Though, both the root and rhizome don't contain Aristolochic acid, the aerial part does. It is known that aristolochic acid induces renal damages. Tuxixin is A. kooyanum Makino var. nipponicum (F. Maekawa) Kitam. It is a kind of (Japanese) "Kan'aoi".
Last renewal date2022/07/28