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| Common name | 苦木, Kumu, Picrasmae Lignum (JP), Picrasmae Ramulus et Folium (CP), Picrasma Wood (JP), Indian Quassiawood (CP) |
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| Original plant name | Picrasma quassioides Bennet , (Nigaki) |
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| Family name | Simaroubaceae |
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| Used part | wood (without bark) |
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| Quality for selection | The one with a strong bitter taste and free from admixed bark is considered to be of good quality. (TN) |
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| Official compendium | JP XIX, CP (2025 ed.) |
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| Clinical application | It is used as a bitter stomachic in the form of powder, tincture, or decoction for the treatment of indigestion, diarrhea, and gastroenteritis. It is also used as an anthelmintic and as a remedy for scabies. |
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| Medical system | Traditional Chinese medicine |
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Drug effect in traditional medicine | Traditional classification | Febrifugal and detoxicant drugs |
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| Beneficial effect | [Property and Flavor] Cold; bitter; slighlty toxic.
[Meridian Tropism] Lung and large intestine meridians.
[Actions] To clear heat and remove toxin, and dispel dampness.
[Indications] Common cold caused by wind-heat, swollen sore throat, dampness-heat diarrhea and dysentery, eczema, sore an d deep-rooted boil, bite wound of insect, worm or snake. |
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| Chemical constituent | Triterpenoids (*C1):
Nigakilactone A, Nigakilactone B, Nigakilactone C, Nigakilactone D(=Quassin), Nigakilactone E, Nigakilactone F, Nigakilactone G(= Picrasin A), Nigakilactone H, Nigakilactone I, Nigakilactone J, Nigakilactone K, Nigakilactone L, Nigakilactone M, Nigakilactone N, Nigakihemiacetal A, Nigakihemiacetal C, Neoquassin, Picrasin A, Picrasin B, Picrasin C, Picrasin D, Picrasin E, Picrasin F, Picrasin G
Benzoquinones (*C1):
2,6-Dimethoxy-p-benzoquinone
Indole alkaloids (*C1):
Nigakinone, Methylnigakinone, 4,5-Dimethoxycanthin-6-one, beta-Carbolin 誘導体/derivatives
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| Chemical structure | |
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| Disease | Dyspepsia, Diarrhea, Gastroenteritis |
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| Formulation | |
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| Related drugs | Jamaica quassia, Surinam quassia |
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| References | JP: The 19th edition of the Japanese Pharmacopoeia.
CP: Pharmacopoeia of the People's Republic of China 2025 edi.
C1)The Encyclopedia of Wakan-Yaku with Color Pictures Vol. II, pp 177-178. |
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| Remarks | Jamaica quassia is the heart wood of Picrasma excelsa Planchon (Jap. name: Jamaicanigaki). Surinam quassia is the heart wood of Quassia amara L. Both are used as an amaroid stomachic. In Japan, Kumu is substituted for these Quassiae Lignums. The branch and leaf are used for removing toxic heat in China. |
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| Last renewal date | 2026/07/07 |
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