Crude drug sample data base

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Crude drug name

Market nameケイヒ [NIB-69]
Formal name桂皮
Japanese nameけいひ, Keihi
Vernacular nameGuipi
Latin nameCinnamomi Cortex (JP), (CP)
English nameCinnamon Bark (JP), Cassia Bark (CP)
Original plant nameCinnamomum sp.
Family nameLauraceae
Used partClassificationPlant origin
Sub classification bark
Production area informationPeople's Republic of China, Guangdong Prov.
Wild or cultivatedCult.
Collection informationJapan, Ibaraki Pref., National Institutes of Biomedical Innovation, Health and Nutrition
Collection date2011/10/20
CollectorKatsuko Komatsu
Remarks[NIB-69]
TMPW No.29215

The capital city, provincial capital city or the representative　　
location of its administrative area is indicated.　　
23.12911
113.26438499999995
Production area information
People's Republic of China,Guangdong Prov.
https://ethmed.toyama-wakan.net/img/pin_san.png
36.3418112
140.4467935
Collection information
Japan,Ibaraki Pref.
https://ethmed.toyama-wakan.net/img/pin_nyu.png

Scientific information data base

Common name桂皮, Guipi, 肉桂, Rougui, Cinnamomi Cortex (JP18, CP2020), Cinnamon Bark (JP18), Cassia Bark (CP2020)
Synonyms広南桂皮, 東興桂皮, ベトナム桂皮, 肉桂
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Original plant nameCinnamomum cassia J. Presl
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Family nameLauraceae
Used partbark
Quality for selectionGuangnan-guipi has thin bark, whereas Vietnamese guipi has thick bark. The inner color of good Guipi is charcoal brown or purplish black. It is pungent and has a fragrant odour. (TN)
Official compendiumJP XVIII, CP (2020 ed.)
Clinical applicationAs diaphoretic, antifebrile, aromatic stomachic and carminative, Guipi is applied for headache, fever, hot flashes, wind-cold, dizziness and body pain. The essential oil of Guipi is used as a corrigent, perfume and spice.
Medical systemTraditional Chinese medicine
Drug effect in
traditional medicine		Traditional
classification		Drugs for dispelling internal cold
Beneficial effect[Property and Flavor] Highly hot; pungent and sweet.
[Meridian Tropism] Kidney, spleen, heart and liver meridians.
[Actions] To tonify and assist yang, conduct fire back to its origin, dissipate cold and relieve pain, warm and unblock the meridian.
[Indications] Impotence and uterine coldness, cold pain in the lower back and knees, wheezing caused by kidney deficiency, upfloating of deficiency yang, dizziness and red eyes, cold pain in the heart and abdomen, deficiency cold vomiting and diarrhea, abdominal pain caused by cold abdominal colic, dysmenorrhea, and amenorrhea.
Chemical constituentOther aliphatic and related compounds
C. verum (*C1):
Cassioside, Cinnamoside

Monoterpenoids
C. verum (*C1):
l-Phellandrene, alpha-Pinene, beta-Pinene, Geranial, Camphene, Linalool, Terpinen-4-ol
C. sieboldii (*C1):
Camphene, Linalool, 1,8-Cineole

Diterpenoids
C. cassia (*C1):
Cinnzeylanine, Cinnzeylanol, Anhydrocinnzeylanine, Anhydrocinnzeylanol, Cinncassiol A, Cinncassiol B, Cinncassiol C1, Cinncassiol C2, Cinncassiol C3, Cinncassiol D1, Cinncassiol D2, Cinncassiol D3, Cinncassiol D4, Cinncassiol E
C. verum (*C1):
Cinnzeylanine, Cinnzeylanol

Phenylpropanoids
C. cassia (*C1):
Cinnamaldehyde(=Cinnamic aldehyde), Cinnamyl acetate, Phenylpropyl acetate, Cinnamic acid, Salicyl aldehyde
C. verum (*C1):
Cinnamaldehyde (= Cinnamic aldehyde), Eugenol
C. sieboldii (*C1):
Cinnamaldehyde (= Cinnamic aldehyde)

Tannins
C. cassia (*C1):
l-Epicatechin, Procyanidin B-2, Procyanidin B-5, Procyanidin C-1, Cinnamtannin I
C. verum (*C1):
l-Epicatechin, Procyanidin B-1, Procyanidin B-2, Procyanidin B-5
(*C2):
Cinnamtannin A1

Chemical structure



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Pharmacological effectSedative, analgesic (water extract, essential oil：excess amount induces spasm). Antibacterial (essential oil：against pathogenic mold). Blepharoptosis, antihypertensive, decrease of temperature, acceleration of respiration, arousal, enhancing bile secretion, inhibition of stress ulcer (cinnamaldehyde). Increasing perspiration, local anesthetic (water extract).
DNA sequenceAB040075, AB040085; Traditioal Medical & Parmaceutical Database.
Classical reference
(Chinese Herbal Classic "Zhenglei bencao")		※Click this image to see the actual image
DiseaseCommon cold, Neuralgia, Rheumatism, Chronic bronchitis, Irregular menstruation, Amenorrhea, Abdominal pain, Diarrhea, Feeling of heavy and dull
FormulationAnchusan, Ifuto, Ireito, Inchingoreisan, Uzukeishito, Unkeito, Unpito, Ogikeishigomotsuto, Ogikenchuto, Ogishakuyakukeishikushuto, Ogibekkoto, Orento, Kakkonto, Kakkonkahangeto, Kakkonkaryojutsubuto, Kakkontokashin'isenkyuto, Kamihassento, Karokeishito, Kangento, Kanzobushito, Kigikenchuto, Gyakubanto, Kyugyakuto, Kumibinroto, Keikyososooshinbuto, Keishito, Keishikaogito, Keishikakakkonto, Keishikakeito, Keishikakobokukyoninto, Keishikashakuyakuto, Keishikashakuyakushokyoninjinto, Keishikashakuyakudaioto, Keishikajutsubuto, Keishikadaioto, Keishikabushito, Keishikaryukotsuboreto, Keishikaryojutsubuto, Keishikanzoto, Keishikanzoryukotsuboreito, Keishikyoshakuyakuto, Keishikyoshakuyakukashokushitsuryukotsuboreito, Keishikyoshakuyakukashokushitsuryukotsuboreikyugyakuto, Keishikyoshakuyakukamaobushisaishinto, Keishigomotsuto, Keishishakuyakuchimoto, Keishishokyokijitsuto, Keishitoninto, Keishinieppiichito, Keishinieppiittokaryojutsubu, Keishinimaoichito, Keishininjinto, Keishibukuryogan, Keishibukuryoganryo, Keishibushito, Keishimaokakuhanto, Kokyuto, Kobokushichimotsuto, Kowashakuyakuto, Kokonrokukenzokumeito, Goshakusan, Goshajinkigan, Gomotsudaioto, Goreisan, Saikatsugekito, Saikokaryukotsuboreito, Saikokeishito, Saikokeishikankyoto, Saikosokanto, Saireito, Shisoshito, Shakanzoto, Sekishozuto, Shahito, Shahitokaryukotsuboreito, Juzentaihoto, Jumizasan, Jurokumiryukiin, Shokenchuto, Shojioto, Shoseiryuto, Shoseiryukasekkoto, Shozokumeito, Shobaito, Sekiganryo (keihi), Sesshoin, Sogento, Zosonmokuboito, Zokumeito, Soshikokito, Daiseiryuto, Daizokumeito, Daibyakuchuin, Chikuhidaigan, Chikuyoto, Jizenippo, Jidabokuippo, Chukenchuto, Chokoshiteito, Chokobukuryoto, Tokakujokito, Tokikenchuto, Tokishigyakuto, Tokishigyakukagoshuyushokyoto, Tokishusan, Tokito, Dokkatsukakkonto, Dokkatsukiseito, Naitaku-san, Naitaku-san, Nyoshinsan, Ninjin-yoei-to, Baimoto, Hachimigangoninjinto, Hachimijiogan, Hachimisenkiho, Hangesanryo, Hangeto, Byakkokakeishito, Bukuryokanzoto, Bukuryokeishikanzodaisoto, Bukuryotakushato, Fushinto, Bunshinkiin, Henseishinkiin, Boijioto, Boibukuryoto, Botanpisan, Hohaito, Hontonto, Hontonto, Hontonto, Hontonto, Hontonto, Honposhakuyakuto, Maoto, Maokajutsuto, Maokaryojutsubuto, Meiroin, Mokuboito, Mokuboikyosekkokabukuryoboshoto, Yokuininto, Ryo-kei-kan-so-to, Ryokito, Ryo-kei-kan-so-to, Ryokeigomikanzoto, Ryokeijutsukanto, Renjuin, Rogyokuto, Rokumotsuogonto, Rokumotsubushito, Fuinto
Related drugsCeylon Cinnamon, Thai Cinnamon, Java Cinnamon
ReferencesJP18: The 18th edition of the Japanese Pharmacopoeia
CP2020: Pharmacopoeia of the People's Republic of China 2020 edi.
C1)The Encyclopedia of Wakan-Yaku with Color Pictures Vol. II, pp 140-142.
C2)Outline of Pharmacognosy, a Textbook, pp 308-309.
RemarksIn China, the bark of C. cassia is called "Rougui" and the tender twigs are called "Guizhi". "Rougui" and "Guizhi" have different beneficial effects. "Rougui" is a medicine for warming up the inside of the body (see "Drug effect in traditional medicine"). The effects of "Guizhi" are to make the body pungent and warm, and dispell pathogenic factors from the exterior of the body. The following are the benefits: dispelling pathogenic factors from the exterior of the body by diaphoresis, warming up and clearing the channels, reinforcing yang and promoting the flow of qi. "Guizhi" is applied to treat common cold, vague pain in epigastric region, blood stasis, aching joints, retention of water in the body, edema, palpitation and running piggy (a feeling of mass of gas ascending within the abdomen like running piggies). In Japan, the usage of C. cassia is similar to that of "Guizhi". Ceylon Cinnamon, the bark of the trunk of C. verum J.S. Presl, is called Cinnamon Bark and it is a well known spice all over the world. Thai Cinnamon is derived from C. iners Reinw. ex Blume and Java Cinnamon is from C. burmanni Blume. Japanese "Nikkei" is the root bark of C. sieboldii Meissn (Jap. name: Nikkei).
- The botanical name has been revised from Cinnamomum cassia Blume to C. cassia J. Presl since its 18th edition of the Japanese Pharmacopoeia.
Last renewal date2023/04/26
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