Crude drug sample data base

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Crude drug name

Market nameチンピ [NIB-665]
Formal name陳皮
Japanese nameちんぴ, Chimpi
Vernacular nameChimpi
Latin nameCitri Unshiu Pericarpium (JP)
English nameCitrus Unshiu Peel (JP)
Original plant nameCitrus unshiu Marcowicz, (Unshūmikan)
Family nameRutaceae
Used partClassificationPlant origin
Sub classification pericarp of mature fruit
Production area informationJapan, Wakayama Pref.
Collection informationJapan, Ibaraki Pref., National Institutes of Biomedical Innovation, Health and Nutrition
Collection date2012/5/30
CollectorKatsuko Komatsu
Remarks[NIB-665]
TMPW No.29271

The capital city, provincial capital city or the representative　　
location of its administrative area is indicated.　　
34.2259867
135.16750860000002
Production area information
Japan,Wakayama Pref.
https://ethmed.toyama-wakan.net/img/pin_san.png
36.3418112
140.4467935
Collection information
Japan,Ibaraki Pref.
https://ethmed.toyama-wakan.net/img/pin_nyu.png

Scientific information data base

Common name陳皮 （日本産/JP production）, Chimpi, Citri Unshiu Pericarpium (JP18), Citrus Unshiu Peel (JP18)
Synonyms青皮, 化州橘皮, 橘皮
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Original plant nameCitrus unshiu Marcowicz1 or Citrus reticulata Blanco, (Unshūmikan1 )
original plant image
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Family nameRutaceae
Used partmature fruit peal
Quality for selectionThe older the better. It has milder aroma than fresh one. Chenpi is a kind of liuchen. (TN)
Official compendiumJP XVII, CP (2020 ed.)
Clinical applicationAs aromatic and bitter stomachic, carminative, expectorant and antitussive drug, it is applied to treat anorexia, vomiting, catharsis, pain and cough. It enters the qi system of lung and spleen, and is applied to upper and middle energizer..
Medical systemTraditional Chinese medicine
Drug effect in
traditional medicine		Traditional
classification		Carminatives for regulating flow of Qi
Beneficial effect[Property and Flavor] Warm; bitter and pungent.
[Meridian Tropism] Lung and spleen meridians.
[Actions] To regulate qi, fortify the spleen, dry dampness and resolve phlegm.
[Indications] Distention and fullness in the epigastrium and abdomen, reduced food intake with vomiting and diarrhea, cough and profuse sputum.
Chemical constituentOther aliphatic and related compounds
C. unshiu (*C1):
クエン酸(citric acid)

Monosaccharides
C. unshiu (*C1):
Vitamin C

Monoterpenoids
C. unshiu (*C1):
Limonene, alpha-Terpinene, alpha-Pinene, beta-Pinene, Linalool, alpha-Thujene, alpha-Terpineol, Myrcene, 1,8-Menthadien-10-ol acetate

Sesquiterpenoids
C. unshiu (*C1):
delta-Elemene, alpha-Copaene, beta-Sesquiphellandrene, alpha-Elemol, alpha-Farnesene, beta-Elemene, delta-Candinene, alpha-Cubebene

Flavones & Flavonols
C. unshiu(*C2,C3,C4,C5):
Isosinensetin, Sinensetin, 5,7,8,4'-Tetramethoxyflavone, Nobiletin, 3,5,6,7,8,3',4'-Heptamethoxyflavone, 3-Hydroxy-5,6,7,8,3',4'-hexamethoxyflavone, Tangeretin, （5-Demethylnobiletin）
C. leiocarpa (*C5):
Isosinensetin, Sinensetin, 5,7,8,4'-Tetramethoxyflavone, Nobiletin, Tangeretin, 5-Demethylnobiletin, (Tetra-O-methylscutellarein, 5-Hydroxy-7,8,3',4'-tetramethoxyflavone)

Flavanones & Dihydroflavonols
C. unshiu (*C1,C2,C4,C5):
Naringenin, Hesperetin, Narirutin, Hesperidin, (Naringin)
C. leiocarpa (*C5):
Narirutin, Hesperidin

Coumarins
C. leiocarpa (*C5):
(Meranzin hydrate, Isomeranzin)

Alkaloids
Citrus spp. (*C6):
Synephrine

Chemical structure






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Pharmacological effectSedative, inhibition of central nervous system, ileum extirpation, contraction of uterus and peripheral blood vessel, mucosal and local stimulation, increase in inner pressure of gallbladder and hypertonia of Sphincter of Oddi, increase in bile secretion, acceleration of intestinal movement, decrease in the level of cholesterol in liver and serum (d-limonene). antiulcer （nobiletin）．Sympathomimetic action （synephrine）．Antiinflammatory （naringin，neohesperidin，nobiletin，tangeretin，sinensetin，xanthotoxin），antiallergic（nobiletin，tangeretin，3-methoxynobiletin，sinensetin），inhibition of c-AMP phosphodiesterase （nobiletin，tangeretin，3-demethylnobiletin）．Strengthening of capillary（hesperidin）, and antioxidant（3,4-dicaffeoylquinic acid）．
DNA sequenceTraditioal Medical & Parmaceutical Database.
Classical reference
(Chinese Herbal Classic "Zhenglei bencao")		※Click this image to see the actual image
DiseaseFull stomach, Vomitting, Diarrhea, Anorexia, Feeling of pressure in the chest, Cough, A lot of sputum
FormulationAnzanto, Ioto, Ikosan, Ireito, Untanto, Orenshodokuin, Kagen'ireito, Kagenshahakusan, Kagenshosaikoto, Kakkoshokisan, Kamiuntanto, Kamihassento, Kyukichoketsuin, Kumihangeto, Kumibinroto, Keihito, Kokikososan, Koshaheiisan, Kosharikkunshito, Kososan, Kochinmuyusan, Goshakusan, Saikokobokuto, Saishakurikkunshito, Jiinkokato, Jiinshihoto, Shisoshito, Shisowakiin, Jippito, Junkiwachuto, Shunrinshakusekishito, Shokitenkoto, Shohito, Shoyosankato, Jokinritsuansan, Jin'en'ippo, Jingyobofuto, Jinsoin, Shimpito, Seishitsuketanto, Seishoekkito, Seisoyoeito, Seineitsugeutsuto, Seihaito, Zenshikunshito, Sogento, Sokeikakketsuto, Soshikokito, Chikujountanto, Chokoshiteito, Chokobukuryoto, Chotosan, Tsudosan, Tokiyoketsuto, Dotaitsukeito, Nijutsuto, Nichinto, Ninjin-yoei-to, Hachimitaikaho, Hangekobokushichimotsuto, Hangebyakujutsutemmato, Fukankinshokisanryo, Bukuryoin, Bukuryhoshinto, Bunshoto, Bunshinkiin, Heiisan, Hointo, Hokikenchuto, Hochuekkito, Hochujishitsuto, Mibakuekkito, Mokutsusan, Yokukansankachinpihangeto, Yokukansankachinpihangeto, Rikkunshito, Rokuutsuto, Koshayoito
Related drugsChenpi (Dried Tangerine Peel produced in China), Qingpi (Green Tangerine Peel), Chengpi (Bitter Orange Peel), Zhiqiao (Orange Fruitproduced in China), Zhishi (Immature Orange Fruit)
ReferencesJP18: The 18th edition of the Japanese Pharmacopoeia.
CP2020: Pharmacopoeia of the People's Republic of China 2020 edi.
C1)The Encyclopedia of Wakan-Yaku with Color Pictures Vol. I, pp 257-260.
C2)Nat.Med.,51,231(1997).
C3)Nat.Med.,51,84(1997).
C4)Nat.Med.,50,114(1996).
C5)Nat.Med.,51,205(1997).
C6)Shoyakugaku Zasshi,46,150(1992).
Remarks80-90% of essential oil is limonene. It is more abundant in ripe fruit peel ("chenpi"/陳皮) than peel of immature fruit ("qingpi"/青皮). Though the older "chenpi" is more appreciated, the components of its essential oil will have changed. Aging increases the relative content of limonene.
Research in recent years reveals methoxyflavonoids including nobiletin have memory-improving effect.
Last renewal date2021/09/27
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