Crude drug sample data base

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Crude drug name

Market nameゴシュユ [NIB-501]
Formal name呉茱萸
Japanese nameごしゅゆ, Goshuyu
Vernacular nameWuzhuyu
Latin nameEuodiae Fructus (JP), (CP)
English nameEuodia Fruit (JP), Medicinal Euodia Fruit (CP)
Original plant nameEuodia (Evodia) sp.
Family nameRutaceae
Used partClassificationPlant origin
Sub classification fruit
Production area informationPeople's Republic of China, Guangxi Zhuangzu Autonomous Region
Collection informationJapan, Ibaraki Pref., National Institutes of Biomedical Innovation, Health and Nutrition
Collection date2012/5/30
CollectorKatsuko Komatsu
Remarks[NIB-501]
TMPW No.29331

The capital city, provincial capital city or the representative  
location of its administrative area is indicated.  
22.817002
108.36654299999998
Production area information
People's Republic of China,Guangxi Zhuangzu Autonomous Region
https://ethmed.toyama-wakan.net/img/pin_san.png
36.3418112
140.4467935
Collection information
Japan,Ibaraki Pref.
https://ethmed.toyama-wakan.net/img/pin_nyu.png

Scientific information data base

Common name呉茱萸, Wuzhuyu, Euodiae Fructus (JP18, CP2020), Euodia Fruit (JP17), Medicinal Euodia Fruit (CP2015)
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Original plant nameEuodia officinalis Dode (Evodia officinalis Dode), Euodia bodinieri Dode (Evodia bodinieri Dode) or Euodia ruticarpa Hooker filius et Thomson1 (Evodia rutaecarpa Bentham) , (Goshuyu1)
original plant image
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Family nameRutaceae
Used partfruit
Quality for selectionGood Wuzhuyu is black and has strong pungency and bitterness. (TN)
Official compendiumJP XVII,CP (2015 ed.)
Clinical applicationAs a stomachic with warm nature, painkiller, diuretic, for relieving vomiting, Wuzhuyu is applied for headache due to rising of noxious fluid, nausea, a feeling of stuffiness in the chest, abdominal pain due to cold of deficiency type, poor circulation and chilblains. It is used as insecticide and bath agent.
Medical systemTraditional Chinese medicine
Drug effect in
traditional medicine
Traditional
classification
Drugs for dispelling internal cold
Beneficial effect[Property and Flavor] Hot; pungent and bitter; slightly toxic.
[Meridian Tropism] Liver, spleen, stomach and kidney meridians.
[Actions] To dissipate cold and relieve pain, downbear counterflow to check vomiting, assist yang to check diarrhea.
[Indications] Reverting yin headache, abdominal pain caused by cold abdominal colic , cold-dampness beriberi, menstruation with abdominal pain, distending pain in the epigastrium and abdomen, vomiting, acid regurgitation, diarrhea before dawn.
Chemical constituentOther aliphatic and related compounds
(*C1):
Goshuyic acid

Monoterpenoids
(*C1):
Ocimene

Triterpenoids
(*C1):
Limonin (= Evodin), Rutaevin, Evodol

Flavanones & Dihydroflavonols
E. rutaecarpa (*C2,C3):
Evodioside B(葉/leaves)

Alkaloids
(*C1):
Evodiamine, Rutaecarpine, Hydroxyevodiamine (= Rhetsinine), Evocarpine, N,N-Dimethyl-5-methoxytryptamine, N-Methylanthranylamide, Synephrine, Higenamine

Purine derivatives
(*C1):
Cyclic GMP

Others
E. rutaecarpa (*C2,C3):
6alpha-Acetoxy-5-epilimonin, 6beta-Acetoxy-5-epilimonin

Chemical structure




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Pharmacological effectIncrease in the blood pressure, accelerated respiration, increase in the blood flow(fraction of alcohol extraction), analgesia, rising temperature (evodiamine, rutaecarpine), inducing labor pains, hemostasis, central excitation (beta-indolethyl-amine), hallucination (N,N-dimethyl-5-methoxytryptamine), adrenergic action, cardiotonic action (synephrine, hygenamine).
Classical reference
(Chinese Herbal Classic "Zhenglei bencao")
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DiseaseHeadache, Nausea, Vomitting, Upper abdominal pain, Coldness of limbs, Lower abdominal pain, Menorrhalgia, Extension of menstrual cycle, Full stomach, Diarrhea, Cold-natured, Chilblain, Stomatitis
FormulationUnkeito, En'nenhangeto, Keimeisan, Keimeisankabukuryo, Goshuyuto, Jinrento, Jizutsuippo, Tokishigyakukagoshuyushokyoto, Tojichuippo, Henseishinkiin, Hontonto, Hontonto
References(JP18): The 18th edition of the Japanese Pharmacopoeia.
(CP2020): Pharmacopoeia of the People's Republic of China 2020 edi.
B1) Nat. Med.,53,275(1999).
C1) The Encyclopedia of Wakan-Yaku with Color Pictures Vol. I, pp 233-234.
C2) Chem.Pharm.Bull.,36,1237(1988).
C3) Chem.Pharm.Bull.,41,1472(1993).
C4) Nat. Med.,52,322(1998).
RemarksIn Japan, the premature fruits of Goshuyu and Hongoshuyu are said to be of high quality.
The Pharmacopoeia of the People's Republic of China 2020 edi. defines nearly matured fruits of Euoodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang as well as the above two species as the original plants. These three premature fruits can be distinguished by the length and diameter of style, presence or absence of the hair, and the size of fruit (B1). In addition, they are different in terms of the chemical components (C4).
Botanically, the right classification is not genus Evodia, but genus Euodia. Goshuyu is Euodia rutaecarpa (Juss.) Benth. Hongoshuyu is E. rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang.
Last renewal date2023/11/16