The Data Base of Ethno-medicines in the world (ETHMEDmmm)

Crude drug sample data base

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Crude drug name	Market name	ショウマ [NIB-901]
	Formal name	升麻
	Japanese name	しょうま, Shōma
	Vernacular name	Shengma
	Latin name	Cimicifugae Rhizoma (JP), (CP)
	English name	Cimicifuga Rhizome (JP), Largetrifoliolious Bugbane Rhizome (CP)
Original plant name		Cimicifuga sp.
Family name		Ranunculaceae
Used part	Classification	Plant origin
Used part	Sub classification	rhizome
Production area information		People's Republic of China, Jilin Prov.
Collection information		Japan, Ibaraki Pref., National Institutes of Biomedical Innovation, Health and Nutrition
Collection date		2014/10/14
Collector		Katsuko Komatsu
Remarks		[NIB-901]
TMPW No.		29613

The capital city, provincial capital city or the representative　　
location of its administrative area is indicated.　　

43.817071

125.32354399999997

Production area information

People's Republic of China,Jilin Prov.

https://ethmed.toyama-wakan.net/img/pin_san.png

36.3418112

140.4467935

Collection information

Japan,Ibaraki Pref.

https://ethmed.toyama-wakan.net/img/pin_nyu.png

Scientific information data base

Common name

升麻, Shengma, Cimicifugae Rhizoma (JP18), (CP2020), Cimicifuga Rhizome (JP18), Largetrifoliolious Bugbane Rhizome (CP2020)

Synonyms

黒升麻, 緑升麻

crude drug image

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Original plant name

Cimicifuga dahurica Maximowicz, Cimicifuga heracleifolia Komarov, Cimicifuga foetida Linn. or Cimicifuga simplex Turczaninow¹, (Sarashinashoma¹)

original plant image

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Family name

Ranunculaceae

Used part

rhizome

Quality for selection

Good Shengma is large without fine roots and the outer surface is black. The cross section is white or light green. (NI)

Official compendium

JP XVIII, CP (2020 ed.)

Clinical application

As an antifebrile, antidote, and anti inflammatory drug, Shengma is applied
for fever, headache, pharyngitis, cold, measles, and anal prolapse.

Medical system

Traditional Chinese medicine

Drug effect in
traditional medicine

Traditional
classification

Diaphoretics with cold property

Beneficial effect

[Property and Flavor] Mild cold; pungent and mild sweet.
[Meridian Tropism] Lung, spleen, stomach and large intestine meridians.
[Actions] To effuse exterior to promote eruption, clear heat and remove toxin, upraise yang qi.
[Indications] Wind-heat headache, toothache, mouth sore, swelling and sore of throat, unerupted measles, macula and papule caused by yang toxin, prolapse of the rectum, uterine prolapse.

Chemical constituent

Triterpenoids
C. dahurica (*C1):
Cimigenol, Cimigenol xyloside, Dahurinol
C. acerina (*C1):
Cimigenol, Acerinol, 25-O-Acetylcimigenol, 25-O-Methylcimigenol, Dehydroxy-15-O-methylcimigenol, 15-O-Methylcimigenol, 25-O-Acetylcimigenoside, 25-O-Methylcimigenoside
(*C6):
Cimigenol 3-arabinoside, Cimigol, Isodahurinol, Acerionol, Cimicifugoside, 26-O-Methylcimifugoside, Cimifugenin A, 26-O-Methylcimifugenin A, Cimicifugenol, Acetylshengmanol xyloside, Friedelin

Triterpenoids
C. foetida (*C1,C3,C4,C5):
Cimicidanol, Foetidinol, Acetylacteol-3-O-arabinoside, 25-Anhydrocimigenol-3-O-beta-xyloside, Cimicidanol-3-O-beta-xyloside, Cimicidol-3-O-beta-xyloside, Cimicifol, Cimicinol, Foetidinol-3-O-beta-xyloside, 15-alpha-Hydroxycimicidol-3-O-beta-xyloside, 15-alpha-Hydroxyfoetidinol-3-O-beta-xyloside

Triterpenoids
C. heracleifolia (*C1,C2,C3):
24-epi-Acerinol, 25-O-Acetyl-7,8-didehydrocimigenol, 7,8-Didehydrocimigenol, 24-epi-7,8-Didehydrocimigenol, Heracleifolinol 3-keto-24-epi-7,8-didehydrocimigenol, 3'-O-Acetyl-24-epi-7,8-didehydrocimigenol-3-O-beta-xyloside, 2',4'-Di-O-acetyl-24-epi-7,8-didehydrocimigenol-3-O-beta-xyloside, 7,8-Didehydro-24-O-acetylhydroshengmanol-3-O-beta-xyloside, 24-epi-7,8-Didehydrocimigenol-3-O-beta-xyloside

Sterols
C. dahurica (*C1):
beta-Sitosterol
C. acerina (*C1):
beta-Sitosterol

Phenylpropanoids
C. dahurica (*C1):
Ferulic acid, Isoferulic acid

Chromones
C. dahurica (*C1):
Visnagin
C. simplex (*C1):
Khellol, Ammiol, Cimifugin
(*C6):
Visamminol

Chemical structure

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Pharmacological effect

Antifebrile, analgesic, antiinflammatory (*E1), sedative, antihypertensive, inhibitior of bone resorption (*C3).

DNA sequence

AB012612, AB029374, AB029375, AB029376, AB029377, AB029378, AB029379, AB029380; Traditioal Medical & Parmaceutical Database.

Classical reference
(Chinese Herbal Classic "Zhenglei bencao")

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Disease

Urticaria, Anal fistula, Pruritus, Hematochezia due to proctoptosis, Descent of the uterus, Measles, Erosion of the root of tooth, Bad breath, Stomatitis, Swelling and pain of the throat, Headache, Chronic diarrhea

Formulation

Ioto, Otsujito, Kumihangeto, Shakuyakushimotsugekito, Shunrinshakusekishito, Shomakakkonto, Joshitsuhokito, Joyowaketsuto, Shin'isan, Shin'iseihaito, Jingyobofuto, Jintanto, Seiishakato, Seinetsuhokito, Tokinentsuto, Hochuekkito, Hochujishitsuto, Rikkosan, Rengyoto

Related drugs

Hongshengma, Guangshengma (see "Remarks")

References

JP18: The 18th edition of the Japanese Pharmacopoeia
CP2020: Pharmacopoeia of the People's Republic of China 2020 edi.
B1)Nat.Med.,50,222(1996);51,148(1997).
C1)The Encyclopedia of Wakan-Yaku with Color Pictures Vol. I, pｐ 30-31.
C2)Chem.Pharm.Bull,41,832(1993).
C3)J.Trad.Med.,13,50(1996).
C4)Tetrahedron,51,1143(1995).
C5)Tetrahedron Lett.,35,4575(1994).
C6)Outline of Pharmacognosy, a Textbook, p 306.
E1)J.Med.Pharm.Soc.WAKAN-YAKU,10,110(1997).

Remarks

The roots of Serratula chinensis S. Moore of family Compositae are used in southern China (Guangshengma). The rhizome of Aruncus sylvester Kostel of family Rosaceae may dilute Shengma derived from genus Cimicifuga rhizoma. Care should be taken with the rhizome of Strobilanthes forrestii Diels of family Acanthaceae that has been distributed as Shengma (fake) in China recently.

Last renewal date

2022/11/02

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