Crude drug sample data base

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Crude drug name

Market nameショウマ [NIB-913]
Formal name升麻
Japanese nameしょうま, Shōma
Vernacular nameShengma
Latin nameCimicifugae Rhizoma (JP), (CP)
English nameCimicifuga Rhizome (JP), Largetrifoliolious Bugbane Rhizome (CP)
Original plant nameCimicifuga sp.
Family nameRanunculaceae
Used partClassificationPlant origin
Sub classification rhizome
Production area informationPeople's Republic of China, Inner Mongolia Autonomous Region
Collection informationJapan, Ibaraki Pref., National Institutes of Biomedical Innovation, Health and Nutrition
Collection date2014/10/14
CollectorKatsuko Komatsu
Remarks [NIB-913]
TMPW No.29623

The capital city, provincial capital city or the representative　　
location of its administrative area is indicated.　　
40.842356
111.74999500000001
Production area information
People's Republic of China,Inner Mongolia Autonomous Region
https://ethmed.toyama-wakan.net/img/pin_san.png
36.3418112
140.4467935
Collection information
Japan,Ibaraki Pref.
https://ethmed.toyama-wakan.net/img/pin_nyu.png

Scientific information data base

Common name升麻, Shengma, Cimicifugae Rhizoma (JP18), (CP2020), Cimicifuga Rhizome (JP18), Largetrifoliolious Bugbane Rhizome (CP2020)
Synonyms黒升麻, 緑升麻
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Original plant nameCimicifuga dahurica Maximowicz, Cimicifuga heracleifolia Komarov, Cimicifuga foetida Linn. or Cimicifuga simplex Turczaninow1, (Sarashinashoma1)
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Family nameRanunculaceae
Used partrhizome
Quality for selectionGood Shengma is large without fine roots and the outer surface is black. The cross section is white or light green. (NI)
Official compendiumJP XVIII, CP (2020 ed.)
Clinical applicationAs an antifebrile, antidote, and anti inflammatory drug, Shengma is applied
for fever, headache, pharyngitis, cold, measles, and anal prolapse.
Medical systemTraditional Chinese medicine
Drug effect in
traditional medicine		Traditional
classification		Diaphoretics with cold property
Beneficial effect[Property and Flavor] Mild cold; pungent and mild sweet.
[Meridian Tropism] Lung, spleen, stomach and large intestine meridians.
[Actions] To effuse exterior to promote eruption, clear heat and remove toxin, upraise yang qi.
[Indications] Wind-heat headache, toothache, mouth sore, swelling and sore of throat, unerupted measles, macula and papule caused by yang toxin, prolapse of the rectum, uterine prolapse.
Chemical constituentTriterpenoids
C. dahurica (*C1):
Cimigenol, Cimigenol xyloside, Dahurinol
C. acerina (*C1):
Cimigenol, Acerinol, 25-O-Acetylcimigenol, 25-O-Methylcimigenol, Dehydroxy-15-O-methylcimigenol, 15-O-Methylcimigenol, 25-O-Acetylcimigenoside, 25-O-Methylcimigenoside
(*C6):
Cimigenol 3-arabinoside, Cimigol, Isodahurinol, Acerionol, Cimicifugoside, 26-O-Methylcimifugoside, Cimifugenin A, 26-O-Methylcimifugenin A, Cimicifugenol, Acetylshengmanol xyloside, Friedelin

Triterpenoids
C. foetida (*C1,C3,C4,C5):
Cimicidanol, Foetidinol, Acetylacteol-3-O-arabinoside, 25-Anhydrocimigenol-3-O-beta-xyloside, Cimicidanol-3-O-beta-xyloside, Cimicidol-3-O-beta-xyloside, Cimicifol, Cimicinol, Foetidinol-3-O-beta-xyloside, 15-alpha-Hydroxycimicidol-3-O-beta-xyloside, 15-alpha-Hydroxyfoetidinol-3-O-beta-xyloside

Triterpenoids
C. heracleifolia (*C1,C2,C3):
24-epi-Acerinol, 25-O-Acetyl-7,8-didehydrocimigenol, 7,8-Didehydrocimigenol, 24-epi-7,8-Didehydrocimigenol, Heracleifolinol 3-keto-24-epi-7,8-didehydrocimigenol, 3'-O-Acetyl-24-epi-7,8-didehydrocimigenol-3-O-beta-xyloside, 2',4'-Di-O-acetyl-24-epi-7,8-didehydrocimigenol-3-O-beta-xyloside, 7,8-Didehydro-24-O-acetylhydroshengmanol-3-O-beta-xyloside, 24-epi-7,8-Didehydrocimigenol-3-O-beta-xyloside

Sterols
C. dahurica (*C1):
beta-Sitosterol
C. acerina (*C1):
beta-Sitosterol

Phenylpropanoids
C. dahurica (*C1):
Ferulic acid, Isoferulic acid

Chromones
C. dahurica (*C1):
Visnagin
C. simplex (*C1):
Khellol, Ammiol, Cimifugin
(*C6):
Visamminol

Chemical structure






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Pharmacological effectAntifebrile, analgesic, antiinflammatory (*E1), sedative, antihypertensive, inhibitior of bone resorption (*C3).
DNA sequenceAB012612, AB029374, AB029375, AB029376, AB029377, AB029378, AB029379, AB029380; Traditioal Medical & Parmaceutical Database.
Classical reference
(Chinese Herbal Classic "Zhenglei bencao")		※Click this image to see the actual image
DiseaseUrticaria, Anal fistula, Pruritus, Hematochezia due to proctoptosis, Descent of the uterus, Measles, Erosion of the root of tooth, Bad breath, Stomatitis, Swelling and pain of the throat, Headache, Chronic diarrhea
FormulationIoto, Otsujito, Kumihangeto, Shakuyakushimotsugekito, Shunrinshakusekishito, Shomakakkonto, Joshitsuhokito, Joyowaketsuto, Shin'isan, Shin'iseihaito, Jingyobofuto, Jintanto, Seiishakato, Seinetsuhokito, Tokinentsuto, Hochuekkito, Hochujishitsuto, Rikkosan, Rengyoto
Related drugsHongshengma, Guangshengma (see "Remarks")
ReferencesJP18: The 18th edition of the Japanese Pharmacopoeia
CP2020: Pharmacopoeia of the People's Republic of China 2020 edi.
B1)Nat.Med.,50,222(1996);51,148(1997).
C1)The Encyclopedia of Wakan-Yaku with Color Pictures Vol. I, pｐ 30-31.
C2)Chem.Pharm.Bull,41,832(1993).
C3)J.Trad.Med.,13,50(1996).
C4)Tetrahedron,51,1143(1995).
C5)Tetrahedron Lett.,35,4575(1994).
C6)Outline of Pharmacognosy, a Textbook, p 306.
E1)J.Med.Pharm.Soc.WAKAN-YAKU,10,110(1997).
RemarksThe roots of Serratula chinensis S. Moore of family Compositae are used in southern China (Guangshengma). The rhizome of Aruncus sylvester Kostel of family Rosaceae may dilute Shengma derived from genus Cimicifuga rhizoma. Care should be taken with the rhizome of Strobilanthes forrestii Diels of family Acanthaceae that has been distributed as Shengma (fake) in China recently.
Last renewal date2022/11/02
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