Crude drug sample data base
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Crude drug name_17389a.jpg/20000) | Market name | Indrajow |
|---|---|---|
| Formal name | Kutaja (Indrayava) | |
Other names Tips！ | Indrajaukarwaa (T), Titaa indrajau (B), Indrajau karwa(H), Kutakapala (M), Amkudu (Te), Kulappalai (Ta), Khuria (N), Kelinda (Sin) | |
| English name | Conessi Seed | |
| Original plant name | Holarrhena pubescens (Buch.-Ham.) Wall. ex DC. (= Holarrhena antidysenterica (L.) Wall.), Conessi Seed | |
| Family name | Apocynaceae | |
| Used part | Classification | Plant origin | Sub classification | seed |
| Production area information | India | |
| Collection information | India, Dibrugarh, Assam , Shree Vishwanath Marwari Databye Aushadhalaya | |
| Collection date | 1997/05/05 | |
| Collector | Katsuko Komatsu, et al. | |
| TMPW No. | 17389 | |
The capital city, provincial capital city or the representative
location of its administrative area is indicated.
location of its administrative area is indicated.
Production area information
India
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27.4728327
94.91196209999998
Collection information
India,Dibrugarh, Assam
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Scientific information data base
| Crude drug name | Ayurvedic name or Sanskrit name, English name | Kutaja (Indrayava) (Seeds), Conessi Seed | ||||
|---|---|---|---|---|---|---|
| Synonyms | Kutaja bija, Yava, Kalinga, Bhadrayava, Sakrahva, Sakrayava, Sakrabija, Vatsaka bija | |||||
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| Original plant name | Holarrhena pubescens (Buch.-Ham.) Wall. ex DC. (= Holarrhena antidysenterica (L.) Wall.) | |||||
| Family name | Apocynaceae | |||||
| Used part | Seeds, Leaves, Bark | |||||
| Distribution area | This is found throughout the drier parts expecially deciduous forests upto 3000 feet, also distributed in tropical Himalayas. | |||||
| Remarks | Common. | |||||
| Common uses | Seeds are astringent, febrifuge in fever, good for dysentery, diarrhea, intestinal worms, bleeding piles, diarrhea, colic and intermittent fevers. Seeds are considered to have similar properties as stem bark, but have milder action. Kutaja and indrayava are made from this. Bark is used in dysentery. It is dried and ground rubbed over the body in dropsy. | |||||
| Therapeutic uses | Jvara (fever), Atisara (diarrhoea/diarrhea), Raktarsa (bleeding piles), Krmi (worms), Visarpa (erysipelas), Kustha (skin disease), Vatasra (arthritic conditions), Sula (colic) | |||||
| Chemical constituent | Others - The therapeutic value of kurchi is due to the presence of alkaloids which occur as tannates. - The total alkaloid content of Indian Kurchi is 0.22-4.2% (av. 2.2%). The average total alkaloid contents in seeds are 1.825%. The principal alkaloid of kurchi is conessine (yield, 0.4%), a stenol with a structure resembling 7-ergosten-3-ol and Y-stigmastenol. | |||||
| Pharmacological effect | Clinical and laboratory trials have shown that conessine and related alkaloids possess amoebicidal properties comparable to emetine. Entamoeba histolytica in mucus flakes is killed by emetine in a dilution of 1in 200,000 and by conessine, in a dilution of 1 in 280,000. Conessine hydrobromide (C24 H40 N2 .2 HBr) is official in International Pharmacopoeia ; it contains not less than 67.5 and not greater than 69.0% conessine. It is prescribed in amoebic dysentery and is considered to be less toxic than the base. | |||||
| Medical system | Ayurveda (Traditional Indian medicine) | |||||
| Traditional concept | Rasa (Taste) | Katu (Pungent), Tikta (Bitter) | ||||
| Virya (Potency) | Sita (Cold) | |||||
| Karma (General action) | Dipana (increasing digestive fire) | |||||
| Dosakarma (Action on dosa) | Decreases all three dosas | |||||
| Dhatukarma(Action on body tissues) | Asra (blood) | |||||
| Mala (Action on excretory mechanism) | Samgrahi (constipative) | |||||
| Formulation | Laghugangadhara curna, Amrtarista, Punarnava mandura and Yogaraja guggulu, Kutajaristam, Kutajatvagadi leham, Ayaskrti | |||||
| Related drugs | Seeds of Wrightia tomentosa Roem & Schult. and W. tinctoria R. Br. of the same family constitue Meetha indrajau of commerce. | |||||
| References | Reference book Tips！ | [2] Indian Medicinal Plants - A Compendium of 500 species, Varier, P.S., Orient Longman Ltd. Chennai (Madras) Vol. 3 (Repr.1996), pp 156-161. Glossary of Indian Medicinal Plants, 1956. Chopra, R.N., Nayar, S.L. and Chopra, I.C., Council of Scientific & Industrial Research, New Delhi. - New Edition (1996) National Institute Science Communication; Supplement pp 134-135. Illustrated Manual of Herbal Drugs Used in Ayurveda, 1996. Sarin, Y.K., Council of Scientific & Industrial Research and Indian Council of Medical Research, New Delhi pp 240-241. Ayurvedic Drugs and Their Plant Sources, 1994. Sivarajan, V.V. and Balachandran, I., Oxford & IBH Publishing Co. Pvt. Ltd., New Delhi pp 267-268. Plants in Ayurveda (A Compendium of Botanical and Sanskrit Names), 1997. Abdul Kareem, M., Foundation for Revitalisation of Local Health Traditions, Bangalore 74. | ||||
| Remarks | Conessine possesses antitubercular activity in situ. It increases coronary outflow in the isolated rabbit heart, induces narcosis in frog, and produces local anaesthesia in guinea pigs, being twice as active as cocaine, but causes necrosis on subcutaneous injection. | |||||
| Last renewal date | 2023/12/25 | |||||
