Crude drug sample data base
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Crude drug name | Market name | Kiules |
|---|---|---|
| Other names | Java: jelumpang, dlumpang, dlumpangan (Javanese), puteran (Sundanese) [201] | |
| English name | Screw plant | |
| Original plant name | Helicteres isora Linn., Screw plant | |
| Family name | Sterculiaceae | |
| Used part | Classification | Plant origin | Sub classification | fruit |
| Collection information | Republic of Indonesia | |
| Collection date | 1993/02/23 | |
| Collector | Tsuneo Namba, et al. | |
| Identifier | Mangestuti Agil | |
| TMPW No. | 16288 | |
Scientific information data base
| Crude drug name | Indonesian name, English name | Kayu ules, Screw plant | ||||
|---|---|---|---|---|---|---|
| crude drug image |
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| Original plant name | Helicteres isora Linn. | |||||
| Family name | Sterculiaceae | |||||
| Used part | Fruits | |||||
| Distribution area | It grows in Java Island of Indonesia [201]. | |||||
| Description | Fruits spiral, brown-black. Seeds small, black. The plant is a woody shrub up to 5 m tall, round in diameter, knotted. Leaves simple, alternate, ovate, apex tapering to acuminate, margin serrate. Inflorescence, male and female, axillary, blue and red when mature [207]. | |||||
| Specific actions | Antispasmodic [201], [PMID:11180523]. | |||||
| Frequency in use | Moderate | |||||
| Pharmacological effect | The antispasmodic activity of the fruits of Helicteres isora was checked in vitro on guinea-pig ileum against three spasmogensm acetylcholine, histamine and barium chloride. The activity was compared with standard antispasmodic agents, atropine and dipheynhydramine hydrochloride. The activity was also studied in vivo by observing the gastrointestinal motility in mice. The results shown that the fruits possess very good antispasmodic activity [PMID:11180523]. The aqueous ethanol and butanol extracts of Helicteres isora root had shown significant protection and lowered the blood glucose levels to normal in glucose tolerant test. A concentrated EtOH extract of the ground root logs yield two potent cytotoxic compounds, identified as cucurbitacin B and isocucurbitacin B. Both compounds have been previously isolated as natural cytotoxic substances [PMID:4031904]. | |||||
| Medical system | Indonesian medicine (Jamu) | |||||
| Traditional usage | It is used in the treatment of abdominal spasms and other stomach upset, alleviating bad body odour [201, 207]. | |||||
| Formulation | 1) Stomach upset: 15 grams of dried fruits are powdered, mixed with 1/2 glass of drinking water, pressed/squeezed and strained. Drink the fresh juice at once [207]. | |||||
| References | Reference book Tips！ | [201] K. Heyne, Tumbuhan Berguna Indonesia, Vols. 1-4, 1987. Diedarkan Oleh Koperasi Karyawan Departemen Kehutanan, Jakarta, Indonesia. Vol. 3, p 1351. [207] Badan Penelitian Dan Pengembangan Kesehatan and Departemen Kesehatan, Kesejahteraan Sosial Ri. Vols. 1-5, Inventaris Tanaman Obat Indonesia, Jakarta, Indonesia. Vol. 3, p 91. | ||||
| Research paper | 1. Pohocha N, Grampurohit ND. Antispasmodic activity of the fruits of Helicteres isora Linn. Phytother Res., 15(1):49-52, 2001. (PMID: 11180523) 2. Bean MF, Antoun M, Abramson D, Chang CJ, McLaughlin JL, Cassady JM. Cucurbitacin B and isocucurbitacin B: cytotoxic components of Helicteres isora. J Nat Prod. 48(3):500, 1985. (PMID: 4031904) 3. P. Ramesh, C. R. Yuvarajan. Cucurbitacin B and Isocucurbitacin B: A new flavone methyl ether from Helicteres isora. J. Nat. Prod., 58(8):1242-1243, 1995. | |||||
| Last renewal date | 2024/03/06 | |||||
