Crude drug sample data base
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Scientific information data base
Crude drug name | Indonesian name, English name | Kayu angin, Old man's beard | ||||
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Original plant name | Usnea sp. | |||||
Family name | Usneaceae | |||||
Used part | Whole plant | |||||
Distribution area | It occurs throughout Indonesia. | |||||
Description | Usnea has some species: 1. Usnea articulata (Linn.) Hoffman 2. U. dasypoga (Acharius) Nylander 3. U. longissima Acharius 4. U. steineri Zahl Bruckner 5. U. vrieseana Montagne et van den Bos hand 6. U. barbata Usnea is not a plant, but it is a symbiotic relationship between an algae and a fungus. It looks like a long, fuzzy strings hanging from trees in the forests. It usually has a greyish green color and grows as a bushy mat from a few inches to two or three feet long, hanging off the trunks and branches. It feels dry and coarse. Some species have an inner core of white material which may be exposed by gently pulling on either end of a strand. It is bitter and astringent. | |||||
Drug effect | Astringent, antibacterial [231]. | |||||
Specific actions | Astringent [231]. | |||||
Frequency in use | Moderate | |||||
Side effect | No known side effects, and it has not been reported to interfere with the action of common medications. It is considered safe for use in children. | |||||
Pharmacological effect | Usnic acid acts as an antibiotic. Sodium usnic acid can accelerate skin wound healing but the effects was not by stimulating proliferation of fibroblasts [PMID:15981883]. Hepatotoxic effect of (+)usnic acid isolated from Usnea siamensis Wainio was studied in rats, isolated rat hepatocytes and isolated rat liver mitochondria. Results indicated that hepatotoxic effect of high dose (+)usnic acid may involve its reactive metabolite(s), causing loss of integrity of membrane like structures, resulting in destruction of mitochondrial respiration and oxidative phosphorylation [PMID:15013205]. Various solvent extracts of the lichen Usnea ghattensis showed good antioxidant activity. These extracts also inhibited the growth of Bacillus licheniformis, Bacillus megaterium, Bacillus subtilis and Staphylococcus aureus with MIC values of 5-10 microg/ml [PMID:16132842]. The antiplatelet and antithrombotic activities of a methanol extract of Usnea longissima, were investigated on platelet aggregation in vitro and on pulmonary thrombosis in vivo. It is shown that the antithrombotic activity of U. longissima extract might be due to antiplatelet activity rather than anticoagulant activity [PMID:16372374]. | |||||
Medical system | Indonesian medicine (Jamu) | |||||
Traditional usage | Usnea dasypoga is considered an important ingredient in Indonesian traditional medicine and sold in the local markets. It is used to treat diarrhoea/diarrhea, gastroenteric problems, dysentery, mouth ulcer, spasms, urinary retention, kidney problems, haemorrhoid/hemorrhoid, menstruation problems. It helps and eases parturition and can be used after parturition as a tonic. It was once used by women of the royal family as an ingredient in face powder, by mixing it with starch and turmeric [201]. To cure diarrhoea/diarrhea, the thallus is boild with water, mixed with ginger and pounded, squeezed. Drink the juice [201]. | |||||
Formulation | 1) Cough: - Ingredients: 1 handful of Usnea sp., 15 pieces of fennel seeds, 1 piece of liquorice (size of an adult finger), 1 handful of Centella asiatica leaves. - Preparation: mix and boil with 110 ml of water to make a decoction. Drink 100 ml of the decoction once a day for 14 days [231]. | |||||
References | Reference book Tips! | [201] K. Heyne, Tumbuhan Berguna Indonesia, Vols. 1-4, 1987. Diedarkan Oleh Koperasi Karyawan Departemen Kehutanan, Jakarta, Indonesia. Vol. 1, pp 75-77. [231] Soedibyo, Mooryati: Alam Sumber Kesehatan: Manfaat dan Kegunaan (Natural resources for health. Benefits and uses). Balai Pustaka. 1998. pp 317-318. | ||||
Research paper | 1. Lee KA, Kim MS. Antiplatelet and antithrombotic activities of methanol extract of Usnea longissima. Phytother Res., 19(12):1061-4, 2005. (PMID: 16372374) 2. Behera BC, Verma N, Sonone A, Makhija U. Antioxidant and antibacterial activities of lichen Usnea ghattensis in vitro. Biotechnol Lett., 27(14):991-5, 2005. (PMID: 16132842) 3. Jin J, Dong Y, He L. The study on skin wound healing promoting action of sodium usnic acid. Zhong Yao Cai, 28(2):109-11, 2005. (PMID: 15981883) 4. Pramyothin P, Janthasoot W, Pongnimitprasert N, Phrukudom S, Ruangrungsi N. Hepatotoxic effect of (+)usnic acid from Usnea siamensis Wainio in rats, isolated rat hepatocytes and isolated rat liver mitochondria. J Ethnopharmacol., 90(2-3):381-7, 2004. (PMID: 15013205) | |||||
Last renewal date | 2024/03/06 |