Crude drug sample data base

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Crude drug name

Market name山査子
Formal name山楂子, 山楂
Japanese nameさんざし, Sanzashiさんざ, Sanza
Vernacular nameShanzhazi, Shanzha
Latin nameCrataegi Fructus (JP), (CP)
English nameCrataegus Fruit (JP), Hawthorn Fruit (CP)
Used partClassificationPlant origin
Sub classification fruit
Production area informationPeople's Republic of China, Shanxi Prov.
Collection informationJapan(ToS), Osaka Pref., Tochimoto Tenkaido Co., Ltd. [Non-commercial Sample]
Collection date2019/07/19
CollectorKatsuko Komatsu
TMPW No.30109

The capital city, provincial capital city or the representative  
location of its administrative area is indicated.  
37.87059
112.54887899999994
Production area information
People's Republic of China,Shanxi Prov.
https://ethmed.toyama-wakan.net/img/pin_san.png
34.6937249
135.5022535
Collection information
Japan(ToS),Osaka Pref.
https://ethmed.toyama-wakan.net/img/pin_nyu.png

Scientific information data base

Common name山楂子(山査子), Shanzhazi, Shanzha, Crataegi Fructus (JP18, CP2020), Crataegus Fruit (JP18), Hawthorn Fruit (CP2020)
Synonyms山楂肉
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Original plant nameCrataegus cuneata Siebold et Zuccarini1, Crataegus pinnatifida Bunge var. major N.E. Brown2, (Sanzashi1, Omisanzashi2)
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Family nameRosaceae
Used partPseudocarp
Quality for selectionGood Shanzhazi is red and large. (NI)
Official compendiumJHMC (1989), CP (2020 ed.), JP XVIII
Clinical applicationAs a remedy for dyspepsia, diarrhea and blood stasis, Shanzhazi is applied for indigestion, stagnation of undigested food with epigastric distention, abdominal pain, diarrhea, gripe, menstrual pain, hyperemesis of after childbirth and hyperlipemia. It is also used for abdominal mass in children, fever, convulsions and peritonitis.
Medical systemTraditional Chinese medicine
Drug effect in
traditional medicine
Traditional
classification
Digestive and evacuants
Beneficial effect[Property and Flavor] Mild warm; sour, sweet.
[Meridian Tropism] Spleen, stomach and liver meridians.
[Actions] To promote digestion and invigorate the stomach, move qi and dissipate stasis, resolve turbidity and lower lipid.
[Indications] Meet food accumulation and stagnation, distention and fullness in the stomach duct, abdominal pain caused by diarrhea and dysentery, blood-stasis amenorrhea, postpartum stasis and obstruction, stabbing pain in heart and abdomen, chest impediment and heart pain, pain caused by genital disease, and hyperlipidemia.
Chemical constituentOther aliphatic and related compounds
(*C1):
Tartaric acid

Triterpenoids
(*C1):
Ursolic acid

Phenylpropanoids
(*C1):
Chlorogenic acid

Flavones & Flavonols
(*C1):
Quercetin

Tannins
(*C2):
(-)-Epicatechin 3-O-gallate, (-)-Epicatechin, Gallic acid, Pyrogallol, 1-(3',4'-Dihydroxyphenyl)-3-(2",4"6"-trihydroxyphenyl)propan-2-ol, 1-(3'-Hydroxyphenyl)-3-(2",4",6"-trihydroxyphenyl)propan-2-ol, 5-(3',4'-Dihydroxyphenyl)gamma-valerolactone, 5-(3'-Hydroxyphenyl)gamma-valerolactone, 5-(3',4'-Dihydroxyphenyl)valeric acid, 5-(3'-Hydroxyphenyl)valeric acid, (3',4'-Dihydroxyphenyl)propionic acid, (3'-Hydroxyphenyl)propionic acid, 5-(3'-Methoxyphenyl)valeric acid, 2",3"-Dihydroxyphenoxyl 3-(3',4'-dihydroxyphenyl)propionate, (+)-Catechin, (-)-Epigallocatechin, (-)-Epigallocatechin gallate, 1-(3',4'-Dihydroxyphenyl)-3-(2",4",6"-trihydroxyphenyl)propan-2-ol, 1-(3'-Hydroxyphenyl)-3-(2",4",6"-trihydroxyphenyl)propan-2-ol

Peptide
(*C1):
脂肪分解酵素 / lipolytic enzyme

Cyanogenic compounds
(*C1):
Amygdalin

Chemical structure



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Pharmacological effectEnhanced secretion of gastric juices, antibacterial (dysentery bacillus).
DNA sequenceU06799, U16190
Classical reference
(Chinese Herbal Classic "Zhenglei bencao")
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DiseaseFull stomach, Abdominal pain, Diarrhea, Lochiometra, Menorrhalgia, Hyperemesis after childbirth, Lower abdominal pain, Measles, Bacterial diarrhea
FormulationKeihito, Ureitsukito, Kagen'ireito, Gyokusuito
Related drugsCrataegi Folium cum Flore (Hawthorn leaf/flower), Crataegi Fructus (Hawthorn berry)
ReferencesJP18: The 18th edition of the Japanese Pharmacopoeia.
CP2020: Pharmacopoeia of the People's Republic of China 2020 edi.
C1) The Encyclopedia of Wakan-Yaku with Color Pictures Vol. I, pp 196-197.
C2) Chem.Pharm.Bull.,45,888(1997).
Remarks- In China, the fruit of Crataegus cuneata Sieb. et Zucc. (Jap. name: Sanzashi) is called Nanshanzha. The fruits of C. pinnatifida Bunge (Jap. name: Ōsanzashi) and C. pinnatifida Bunge var. major N.E. Brown (Jap. name: Ōmisanzashi) are called Beishanzha. The Japanese Pharmacopoeia difines Sanzashi and Ōmisanzashi, while the Chinese Pharmacopoeia defines Ōmisanzashi and Ōsanzashi. There are many agrotypes in Ōsanzashi, which are used for food.
- In Europe, the extract of leaves and flowers of C. monogyna Jacq. and C. laevigata (Poiret) DC. (both are not classified in Japan and called just Seiyōsanzashi) are used as cardiac, antihypertensive and antiasthenic drug. It is applied to treat coronary artery diseases, arteriosclerosis, senile diseases and so on. The fruit of Seiyōsanzashi is also used in the same way.
Last renewal date2022/10/25