Crude drug sample data base

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Crude drug name

Market nameセンブリ
Formal nameセンブリ
Japanese nameせんぶり, semburi
Vernacular namesemburi
Latin nameSwertiae Herba (JP)
English nameSwertia Herb (JP)
Original plant nameSwertia japonica Makino , (Semburi)
Family nameGentianaceae
Used partClassificationPlant origin
Sub classification whole plant
Production area informationJapan, Nagano Pref.
Collection informationJapan, Gifu Pref., Alps Pharmaceutical lnd. Co., Ltd.
Collection date2005/04/28
CollectorKatsuko Komatsu
RemarksLot.05D3S
TMPW No.30201

The capital city, provincial capital city or the representative  
location of its administrative area is indicated.  
36.6512986
138.18095570000003
Production area information
Japan,Nagano Pref.
https://ethmed.toyama-wakan.net/img/pin_san.png
35.3912272
136.72229059999995
Collection information
Japan,Gifu Pref.
https://ethmed.toyama-wakan.net/img/pin_nyu.png

Scientific information data base

Common nameセンブリ, Semburi, Swertiae Herba (JP18), Swertia Herb (JP18)
Synonyms当薬
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Original plant nameSwertia japonica Makino, (Semburi)
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Family nameGentianaceae
Used partwhole plant in flowering time
Quality for selectionGood Semburi has lots of flowers and leaves, which are harvested on the early stages of inflorescence. (TN)
Official compendiumJP XVIII
Clinical applicationIt is an aromatic stomachic. It is also used to stimulate hair growth, provide sadation and lessen inflammation.
Medical systemFolk medicine
Chemical constituentMonoterpenoids
Secoiridoids:
(*C1):
Swertiamarin, Sweroside, Gentiopicroside, Amarogentin, Amaroswerin
S. japonica (*C6,C7):
Swertiamarin, Sweroside,
以下代謝物 [The following compounds are the metabolites] 4,4beta-5alpha,6alpha-Tetrahydro-5beta-hydroxymethyl-6beta-methyl-1H,3H-pyrano[3,4-c]pyran-1-one, Epinaucledal, Naucledal
(*C9):
Gentiopicrin

Triterpenoids
(*C1):
Oleanolic acid, Thysanolactone

Xanthones
(*C1):
Norswertianin, Swertianin, Methylswertianin, Swertianolin, Desmethylbellidifolin, Bellidifolin(=Swertianol), Methylbellidifolin
S. japonica (*C2-C5):
Tetrahydroswertianolin, 1,3,6,7-Tetrahydroxyxanthone
S. chirata (*C8):
Mangiferin, 1,3,6,7-Tetrahydroxyxanthone
(*C9):
Swertinogen

Flavonoids
(*C1):
Swertisin, Swertiajaponin, Homoorientin, Isovitexin
S. japonica (*C4,C5):
Homoorientin, 6-C-Glucosyleriodictyol, (±)-Eriodictyol, Luteolin

Phenol derivatives
S. japonica (*C4,C5):
Phloroglucinol

Other aromatic derivatives
S. japonica (*C6,C7):
Erythrocentaurin, Hydroxymethyl isochroman-1-one

Pyridine alkaloids
S. japonica (*C6):
Gentianine

Chemical structure




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Pharmacological effectSecretion of gastric juices (gentiopicrin:enhancement;genitianine:suppression;swertinogen:enhancement at low doses and suppression at high doses).Enhanced secretion of bile and pancreatic juice. Antiulcer(gentianine). Improvement of function of liver,dilatation of capillary,activation of skin cells, stimulation of hair growth (swertinogen). Hypoglycemic (bellidifolin).
DNA sequenceAF102486, AJ010528, AJ011457; Traditioal Medical & Parmaceutical Database.
DiseaseStomachache, Abdominal pain
FormulationBitter Tincture, Sodium Bicarbonate and Bitter Tincture, Swertia and Sodium Bicarbonate Powder, Magnesium Sulfate Mixture
Related drugsChirayta (see "Remarks")
ReferencesJP18: The 18th edition of the Japanese Pharmacopoeia.
C1)The Encyclopedia of Wakan-Yaku with Color Pictures Vol. II, pp 46-47.
C2)Chem.Pharm.Bull.,45,567(1997).
C3)Chem.Pharm.Bull.,45,1823(1997).
C4)Natural Drugs and the Digestive Tract,299(1992).
C5)J.Nat.Prod.,51,874(1988).
C6)Planta Med.,55,147(1989).
C7)Shoyakugaku Zasshi,44,122(1990).
C8)Phytochemistry,28,1289(1989).
C9)Pharmacology of Medicinal Herbs in East Asia, pp 237-240.
RemarksIt is a typical Japanese folk medicine. It was blended in Japanese medicine "Hangontan" as the substitute for Chinese crude drug "Huhuanglian". "Huhuanglian" is the rhizome of Picrorrhiza scrophulariiflora Pennell or P. kurrooa Royle ex Benth. Chirayta (Chirata, Chiretta, Kiratatikta) is the whole plant of Swertia chirayta (Roxb.) Karst. and listed in the medical book of Ayurveda, "Caraka Samhita".
It has effect of decreasing excess Kapha Dosa, or phlegmatic temperament, and is applied to treat diseases of blood vessels and skin.
Last renewal date2022/10/25