Crude drug sample data base

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Crude drug name

Market name川楝子
Formal name川楝子
Japanese nameせんれんし, Senrenshi
Vernacular nameChuanlianzi
Latin nameMeliae Fructus (Non-JPS), Toosendan Fructus (CP)
English nameMelia Fruit (Non-JPS), Szechwan Chinaberry Fruit (CP)
Used partClassificationPlant origin
Sub classification fruit
Production area informationPeople's Republic of China, Sichuan Prov.
Collection informationJapan（ToS）, Osaka Pref., Tochimoto Tenkaido Co., Ltd. [Non-commercial Sample]
Collection date2021/12/07
CollectorKatsuko Komatsu
TMPW No.31145

The capital city, provincial capital city or the representative　　
location of its administrative area is indicated.　　
30.572815
104.06680099999994
Production area information
People's Republic of China,Sichuan Prov.
https://ethmed.toyama-wakan.net/img/pin_san.png
34.6937249
135.5022535
Collection information
Japan（ToS）,Osaka Pref.
https://ethmed.toyama-wakan.net/img/pin_nyu.png

Scientific information data base

Common name川楝子, Chuanlianzi, Meliae Fructus (Non-JPS2022), Toosendan Fructus (CP2020), Melia Fruit (Non-JPS2022), Szechwan Chinaberry Fruit (CP2020)
Synonyms苦楝子（Kulianzi）
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Original plant nameMelia toosendan Siebold et Zuccarini1 or Melia azedarach Linn. var. subtripinnata Miquel2 , (Tōsendan1, Sendan2)
original plant image
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Family nameMeliaceae
Used partmature fruit
Official compendiumCP (2020 ed.), Non-JPS (2022)
Clinical applicationAs an anthelmintic and analgesic, it is applied to treat colic caused by ascaridiasis, stomach and abdominal pain.
Medical systemTraditional Chinese medicine
Drug effect in
traditional medicine		Traditional
classification		Carminatives for regulating flow of Qi
Beneficial effect[Property and Flavor] Cold; bitter; slighlty toxic.
[Meridian Tropism] Liver, small intestine and bladder meridians.
[Actions] To soothe the liver and discharge heat, move qi to relieve pain, kill worms.
[Indications] Depressed liver qi transforming into fire, distending pain in the chest, hypochondrium, epigastrium and abdomen, pain caused by genital disease, abdominal pain caused by worm accumulation.
Chemical constituentTriterpenoids
M. azedarach (*C1,C6-C19):
Meldenin, Nimbinin, Melianin A, Melianol, Melianone, Meliatoxin A1, Meliatoxin A2, Meliatoxin B1, Meliatoxin B2, Melianotriol, Melianodiol, Nimbolidin A, Nimbolidin B, Nimbolin A, Nimbolin B, Azedarachol, Kulactone, Kulinone, Sendanolactone, Sendandal, Sendanin
M. toosendan (*C2-C4):
21-O-Acetyltoosendantriol, 21-O-Methyltoosendanpentol, Lipomelianol

Others
M. toosendan (*C5):
Meliainoside A, Meliainoside B
M. azedarach (C13,C20,C21):
Nimbolinin A, Nimbolinin B, Ohchinolide A, Ohchinolide B, Ohchinal Ohchinin, Ohchinin acetate, Ohchinolal

Chemical structure





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Pharmacological effectIt has a strong larvicidal action on pig roundworms, earthworms and bloodsuckers in vitro. Rat pinworms (Aspicularis tetraptera) were killed completely by the 25% solution within 12 hours. Its preparation was effective in a stomachache clinically. Its oil ointment was also effective in Trichophyton of head.
Classical reference
(Chinese Herbal Classic "Zhenglei bencao")		※Click this image to see the actual image
DiseaseRoundworm, Enterobiasis, Stomachache, Lower abdominal pain, Restlessness, Feeling of bitter in the mouth, Thirst, Dryness of tongue, Scrotal shrinkage, Swelling and pain of testis, Pain of testis
FormulationShobaito
Related drugsKulianpi (Chuanlianpi) = Melia bark, Nimba (Neem)
ReferencesNon-JPS2022: The Japanese standards for non-Pharmacopoeial crude drugs 2022.
CP2020: Pharmacopoeia of the People's Republic of China 2020 edi.
C1)The Encyclopedia of Wakan-Yaku with Color Pictures Vol. I, pp 247-248.
C2)Chem. Lett., 69 (1986).
C3)Heterocycles, 28, 383 (1989).
C4)Chem. Pharm. Bull., 34, 100 (1986).
C5)Chem. Pharm. Bull., 39, 2529 (1991).
C6)J. Chem. Soc., Perkin Trans., 1, 1352 (1975).
C7)J. Chem. Soc. C., 820 (1967).
C8)Chem. Pharm. Bull., 40, 1053 (1992).
C9)J. Am. Chem. Soc., 103, 1228 (1981).
C10)Phytochemistry, 22, 531 (1983).
C11)J. Chem. Soc., Chem. Commun., 910 (1967).
C12)J. Chem. Soc., Chem. Commun., 261 (1971).
C13)Chem. Ber., 114, 267 (1981).
C14)J. Chem. Soc., Chem. Commun., 1166 (1969).
C15)Phytochemistry, 24, 1945 (1985).
C16)Tetrahedron, 29, 1911 (1973).
C17)Bull. Chem. Soc. Jpn., 50, 2499 (1977).
C18)Chem. Lett., 621 (1978).
C19)Tetrahedron Lett., 2877 (1976).
C20)Chem. Lett., 331 (1978).
C21)Bull. Chem. Soc. Jpn., 56, 1139 (1983).
RemarksIn case Chuanlianzi derived from Melia toosendan Sieb. et Zucc. (Jap. name: Tōsendan) was insufficient, the fruit of congener M. azedarach L. var. azedarach (Jap. name: Tokiwasendan) is sometimes substituted for it. The fruit of M. azedarach L. var. subtripinnata Miq., Japanese Sendan, is not available in the market.
Kurenpi is the bark or root bark of Tōsendan or Tokiwasendan. Though it has the same effects as Chuanlianzi, the bark has stronger insecticidal effect and the fruit has stronger analgesic effect. Nimba is Melia azadirachta L. (= Azadirachta indica A. Juss.). It is a typical Ayurvedic drug and the parts used are the bark, leaf, flower, fruit and seed.
Last renewal date2022/07/20
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