Crude drug sample data base

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Crude drug name

Market nameコウボク [NIB-408]
Formal name厚朴
Japanese nameこうぼく, Kōboku
Vernacular nameKōboku
Latin nameMagnoliae Cortex (JP)
English nameMagnolia Bark (JP)
Original plant nameMagnolia obovata Thunb., (Hōnoki)
Family nameMagnoliaceae
Used partClassificationPlant origin
Sub classification bark
Production area informationJapan, Niigata Pref.
Collection informationJapan, Tochigi Pref., National Institutes of Biomedical Innovation, Health and Nutrition
Collection date2022/07/26
CollectorKatsuko Komatsu
Remarks[NIB-408]
TMPW No.31603

The capital city, provincial capital city or the representative　　
location of its administrative area is indicated.　　
37.9025518
139.02309460000004
Production area information
Japan,Niigata Pref.
https://ethmed.toyama-wakan.net/img/pin_san.png
36.565725
139.88356509999994
Collection information
Japan,Tochigi Pref.
https://ethmed.toyama-wakan.net/img/pin_nyu.png

Scientific information data base

Common name厚朴, Houpo, Magnoliae Cortex (JP18), Magnoliae Officinalis Cortex (CP2020), Magnolia Bark (JP18), Officinal Magnolia Bark (CP2020)
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Original plant nameMagnolia obovata Thunberg1 (= Magnolia hypoleuca Siebold et Zuccarini), Magnolia officinalis Rehder et E. H. Wilson or Magnolia officinalis Rehder et E. H. Wilson var. biloba Rehder et E. H. Wilson, (Hōnoki1)
original plant image
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Family nameMagnoliaceae
Used parttrunk and blanch bark
Quality for selectionThe outside of good Houpo is deep violet and the inside has longitudinal crests. The bark is very thick and dense. The fresh one, which tastes a little bitter, is good. (NI)
Official compendiumJP XVIII, CP (2020 ed.)
Clinical applicationAs an antispasmodic, painkiller, stomachic, astringent, expectorant and diuretic, Houpo is applied for abdominal distention and pain, cough and asthma, and abnormal tension of skeletal muscle with anxiety, mental strain and all.
Medical systemTraditional Chinese medicine
Drug effect in
traditional medicine		Traditional
classification		Aromatic drugs for resolving dampness
Beneficial effect[Property and Flavor] Warm; bitter, pungent.
[Meridian Tropism] Spleen, stomach, lung and large intestine meridians.
[Actions] To dry dampness, resolve phlegm, direct qi downward, and disperse fullness.
[Indications] Dampness stagnation damaging ,the middle, epigastric stuffiness, vomiting, diarrhea, food retention, qi stagnation, abdominal distension, constipation, and wheezing and cough caused by phlegm-fluid retention.
Chemical constituentMonoterpenoids
M. obovata (*C1):
alpha-Pinene, beta-Pinene, Camphene, Limonene, Bornyl acetate

Sesquiterpenoids
M. obovata (*C1):
alpha-Eudesmol, beta-Eudesmol(= Machilol), gamma-Eudesmol, Cryptomeridiol, Eudesobovatol A, Eudesobovatol B, Caryophyllene epoxide
M. officinalis (*C1):
beta-Eudesmol

Phenylpropanoids
M. obovata (*C1):
Magnolo l(= bis-Chavicol), Honokiol, Magnoloside A, Magnoloside B, Magnoloside C
M. officinalis (*C1):
Magnolol, Honokiol
M. officinalis, M. obovata (*C3,C4,C5):
Magnolol, Honokiol, 以下代謝物 / the followings are the metabolites Tetrahydromagnolol, 5-(1-Propen-1(E)-yl)-5'-propyl-2,2'-dihydroxybiphenyl, 5-Allyl-5'-(1-propen-1(E)-yl)-2,2'-dihydroxybiphenyl, Isomagnolol, 5-Allyl-5'-propyl-2,2'-dihydroxybiphenyl
(*C6):
Magnolol
M. obovata 葉/leaf (*C2):
Obovatal, Obovatol

Isoquinoline alkaloids
M. obovata, M. officinalis (*C1):
Magnocurarine, Magnoflorine, Michelalbine, Anonaine, Liriodenine, Salicifoline chloride
M. officinalis, M. obovata (*C5):
Magnocurarine, Magnoflorine

Chemical structure




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Pharmacological effectRelaxation of muscles (water extract）．Sedation，suppression of righting reflex，suppression of spinal reflex，antispasm and antitremor （ether extract）．Myoneural junction blokade，transient decrease in blood sugar（magnocurarine）．Sedation，central relaxation of muscles，dental caries protection （magnolon，honokiol），antibacterial and insecticidal，antiparkinsonism （magnolol）．
DNA sequenceAB020999, AB021013, AB021000; Traditioal Medical & Parmaceutical Database.
Classical reference
(Chinese Herbal Classic "Zhenglei bencao")		※Click this image to see the actual image
DiseaseFull stomach, Abdominal pain, Constipation, Diarrhea, Cough, Dyspnea
FormulationAnzanto, Ireito, Inchinsan, Unpito, Kagen'ireito, Kakkoshokisan, Kamijokito, Kamiheiisan, Kanchuto, Kumibinroto, Keishikakobokukyoninto, Gohekiin, Kobokusammotsuto, Kobokushichimotsuto, Kobokushokyohangekanzoninjinto, Kobokumaoto, Kobokuto, Goshakusan, Saikokobokuto, Saibokuto, Shisoshito, Jippito, Shakuyakutokadaio, Shahito, Shahitokaryukotsuboreito, Jurokumiryukiin, Junchoto, Shosaikogohangekobokuto, Shojokito, Shobaito, Shohito, Jin'en'ippo, Shimpito, Zenshikunshito, Soshikokito, Daijokito, Jizenippo, Chokoshiteito, Tsudosan, Tokito, Hangekobokuto, Fukankinshokisanryo, Bunshoto, Heiisan, Hokikenchuto, Hochujishitsuto, Chuseito, Tokiyoketsuto, Naitaku-san, Naitaku-san, Hangekobokushichimotsuto, Binrojunkito, Kaishun'inchinsan, Koshayoito
Related drugsMagnolia Flower
ReferencesJP18: The 18th edition of the Japanese Pharmacopoeia.
CP2020: Pharmacopoeia of the People's Republic of China 2020 edi.
C1) The Encyclopedia of Wakan-Yaku with Color Pictures Vol. II, pp 145-147.
C2) Chem.Pharm.Bull.,30,3347(1982).
C3) Chem.Pharm.Bull.,32,5010(1984).
C4) Chem.Pharm.Bull.,34,158(1986).
C5) J.Med.Pharm.Soc.WAKAN-YAKU,3,129(1986).
C6) Shoyakugaku Zasshi,42,130(1988).
RemarksThe Japanese Pharmacopoeia defines three kinds of bark as Houpo and it is required to contain not less than 0.8% of magnolol. The Pharmacopoeia of People's Republic of China defines Houpo, Magnoliae Officinalis Cortex, as the bark of M. officinalis (Chuanpo, Hubeipo, etc) and M. officinalis var. biloba (Wenpo, Wenzhouhoupo). Aside from the bark (trunk bark, branch bark), the root bark is also used. In the Japanese market, Chinese houpo is named generically as Tokoboku. In Korea, as well as the bark of M. officinalis, the bark of Machilus thunbergii Sieb. et Zucc. of family Lauraceae (Jap. name: Tabunoki) is substituted. Though it is called Houpo or Baopo, the properties and flavors are completely different.
Last renewal date2023/12/06
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