Crude drug sample data base

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Crude drug name

Market name蟾蜍
Formal name蟾蜍
Japanese nameせんそ, Senso
Vernacular nameChansu
Latin nameBufonis Crustum (JP), Bufonis Venenum (CP)
English nameToad Cake (JP), Toad Venom (CP)
Original plant nameBufo bufo gargarizans Cantor1, Bufo bufomelanosticus Schneider, (Shinahikigaeru1, Herigurohikigaeru)
Family nameBufonidae
Used partClassificationAnimal origin
Collection informationRepublic of Korea, Seoul City
Collection date1982/07/30
CollectorTsuneo Namba
TMPW No.5640

The capital city, provincial capital city or the representative　　
location of its administrative area is indicated.　　
Production area information
https://ethmed.toyama-wakan.net/img/pin_san.png
37.566535
126.97796919999996
Collection information
Republic of Korea,Seoul City
https://ethmed.toyama-wakan.net/img/pin_nyu.png

Scientific information data base

Common name蟾酥, Chansu, Bufonis Crustum (JP18), Bufonis Venenum (CP2020), Toad Cake (JP18), Toad Venom (CP2020)
Original plant nameBufo bufo gargarizans Cantor1, Bufo melanosticus Schneider, (Asiahikigaeru1)
original plant image
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Family nameBufonidae
Used partparotoid secretion
Quality for selectionToso is disciform. Kishiso is smaller disciform. Good Chansu is slightly lustrous and dark brown. Preferably, it has no contamination of starch and other materials. (TN)
Official compendiumJP XVIII，CP (2020 ed.)
Clinical applicationAs a tonic, painkiller and antidote, Chansu is applied for hot-tempered child, stomach pain, diarrhea, jaundice, cardiac disease, and intestinal parasite infection. It is used externally for eye disease like conjunctivitis, hemorrhoid and pain due to swelling.
Medical systemTraditional Chinese medicine
Drug effect in
traditional medicine		Traditional
classification		External drugs
Beneficial effect[Property and Flavor] Warm; pungent; toxic.
[Meridian Tropism] Heart meridian.
[Actions] To remove toxin, and relieve pain, open the orifices and enliven the spirit.
[Indications] Abscesses and cellulitis, deep-rooted boil and sore, swollen sore throat, loss of consciousness caused by summer heat stroke, vomiting and diarrhea with abdominal pain caused by Sha Zhang (acute gastrointestina infection).
Chemical constituentOther aliphatic and related compounds
(*C1):
Suberic acid

Sterols
(*C1):
Cholesterol, 7alpha-Hydroxycholesterol, 7beta-Hydroxycholesterol, Ergosterol, Campesterol, beta-Sitosterol

Toad poison
Cardiac Steroids:
(*C1):
Bufalin, Cinobufotalin, Resibufogenin, Cinobufagin, Gamabufotalin, Telocinobufagin, Hellebrigenin, Arenobufagin, psi-Bufarenogin, Cinobufaginol, Marinobufagin, Resibufagin, Bufadienolides, Cardenolides, Gamabufotoxin, Vulgarobufotoxin, Alvarobufotoxin, Arenobufotoxin, Cinobufotoxin, Fowlerobufotoxin, Marinobufotoxin, Regularobufotoxin, Viridobufotoxin

Amino acids
(*C1):
Arginine

Indole alkaloids
(*C1):
Bufotenine, Bufotenidine, Serotonin, Bufothionine, Dehydrobufotenine

Other nitrogen containing compounds
(*C1):
Adrenaline

Chemical structure






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Pharmacological effectEnhanced contraction of heart muscle, respiratory excitation, local anesthesia (cardiotonic steroid), nicotinic action (bufotenidine), hallucination (bufotenine), inhibition of vascular permeability (water extract).
DNA sequenceAF160785, U52796
DiseasePyogenic dermatosis, Swelling and pain of the throat, Disturbance of consciousness, Vomitting, Diarrhea, Abdominal pain
FormulationRokushingan
References(JP18): The 18th edition of the Japanese Pharmacopoeia.
(CP2020): Pharmacopoeia of the People's Republic of China 2020 edi.
C1) The Encyclopedia of Wakan-Yaku with Color Pictures Vol. II, pp 266-270.
RemarksThe toad venom has been famous as the toad oil since ancient times. Chansu is specified as poison, but its constituent, bufalin, is the most effective in cardiotonic and local anesthetic. It is the raw material for cardiotonic and "Gokan", or five infantile malnutritions, such as "Rokushingan", "Kyūshin, "Kiōgan", etc.
Last renewal date2024/04/03
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