Crude drug sample data base

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Crude drug name

Market name熟地黄
Formal name地黄
Japanese nameじゅくじおう, Jukujiō; じおう, Jiō
Vernacular nameShu-dihuang, Dihuang
Latin nameRehmanniae Radix Preparata, Rehmanniae Radix
English namePrepared Rehmannia Root
Original plant nameRehmannia glutinosa Libosch., Kaikeijiō
Family nameScrophulariaceae
Used partClassificationPlant origin
Sub classification tuberous root
TMPW No.620

Scientific information data base

Common name熟地黄, Shudihuang, Rehmanniae Radix Preparata (CP2020), Prepared Rehmannia Root (CP2020)
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Original plant nameRehmannia glutinosa Liboschitz var. purpurea Makino 1 or Rehmannia glutinosa Liboschitz, (Akayajiō1)
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Family nameScrophulariaceae
Used partthickenin root
Quality for selectionGood Shudihuang is enlarged, black and has lustrous shining. It tastes sweet. (NI)
Official compendiumJP XVII, CP (2020 ed.)
Clinical applicationAs a tonifying and heat-clearing drug, for reducing heat in blood, shudihuang is applied for anemia, hematemesis, diabetes, night sweat, pollution, mental instability and infirmity.
Medical systemTraditional Chinese medicine
Drug effect in
traditional medicine
Traditional
classification
Drugs for replenishing Yin-vital essence
Beneficial effect[Property and Flavor] Mild warm; sweet.
[Meridian Tropism] Liver and kidney meridians.
[Actions] To nourish blood, replenish yin, replenish the essence and the marrow.
[Indications] Blood deficiency, sallow complexion, palpitations, fearful throbbing, menstrual irregularities, menstrual flooding and spotting, liver-kidney yin deficiency, soreness and weakness in the low back and knees, bone-steaming and tidal fever, night sweating seminal emission, interior heat, wasting-thirst, dizziness, tinnitus, and premature graying.
Chemical constituentLipids
(*C1):
Cerebroside, Jio-cerebroside

Sugar
(*C1):
Manninotriose, Verbascose

Monosaccharides
(*C1):
D-Mannitol, D-Glucose, D-Fructose, D-Galactose

Oligosaccharides
(*C1):
Raffinose, Stachyose, Sucrose

Monoterpenoids
Iridoids:
(*C1):
Catalpol, Aucubin, Rehmannioside A, Rehmannioside B, Rehmannioside C, Rehmannioside D, Rehmaionoside A, Rehmaionoside B, Rehmaionoside C, Rehmaionoside D, Melittoside, Leonuride

Carotenoids & Vitamin A
(*C2):
Vitamin A

Sterols
(*C1):
Sitosterol

Phenol derivatives
(*C1):
Acteoside

Amino acids
(*C2):
Arginine

Others
(*C2):
鉄/Fe

Chemical structure


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Pharmacological effectHypoglycemic,cardiotonic,hypertensive,diuretic (extract). Cathartic and diuretic(catalpol).
DNA sequence Traditioal Medical & Parmaceutical Database.
Classical reference
(Chinese Herbal Classic "Zhenglei bencao")
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DiseaseLightheadedness, Vertigo, Bleary eyes, Palpitation, Irregular menstruation, Menorrhalgia, Irregular vaginal bleeding, Pain due to flatulence of hypochondrium, Night sweats
FormulationIshoho, Unseiin, Ekkiyoeito, Kagenhachimotsuto, Kanroin, Kibanto, Kyukichoketsuin, Saikoshimotsuto, Jijinmeimokuto (Jinkimeimouto), Shimotsuto, Shimotsutokakibansetsuketsumei, Shimotsutokakkekagen, Juzentaihoto, Junchoto, Jinkimeimokuto, Seinetsuhoketsuto, Daibofuto, Tokiyoketsuto, Tokirokuoto, Hachimotsuto, Hacchinto, Hointo, Rokumijiogan, Kogikujiogan
Related drugsGandihuang (Dried Rehmannia Root), Xiandihuang (Fresh Rehmannia Root)
ReferencesJP18: The 18th edition of the Japanese Pharmacopoeia.
CP2020: Pharmacopoeia of the People's Republic of China 2020 edi.
C1)The Encyclopedia of Wakan-Yaku with Color Pictures Vol. I, pp 63-64.
C2)Outline of Pharmacognosy, a Textbook, p229.
Remarks"Shudihuang" is processed with wine: it is made by steaming after mixing with "Huangjiu", a kind of rice wine such as "Shaoxingjiu". Then it is dried by daylight. This process, steaming and drying, is repeated 9 times.
Steamed "Shudihuang": it is made by steaming without "Huangjiu". The steaming and drying process is repeated 9 times too. Comparing with "Kanjiō" (Unprepared Rehmannia Root), "Shudihuang" tends to have less or no iridoid glycoside such as catalpol, and has more monosaccharides.
Last renewal date2024/10/04