Crude drug sample data base

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Crude drug name

Market nameKulit Delima Putih
Other namesJava: gangsalan (Javanese), Dhalima (Madurese);Sumatra: dalimo (Batak) [201]
English namePomegranate
Original plant namePunica granatum Linn., Pomegranate
Family namePunicaceae
Used partClassificationPlant origin
Sub classification fruit peal, pericarp
Collection informationRepublic of Indonesia, Akar sari
Collection date1994/02/27
CollectorKatsuko Komatsu, et al.
IdentifierMangestuti Agil
TMPW No.14182

Scientific information data base

Crude drug nameIndonesian name,
English name		Kulit buah delima, Pomegranate
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Original plant namePunica granatum Linn.
Family namePunicaceae
Used partFruits, flowers, roots
Distribution areaIt is cultivated in Java in home gardens [201].
DescriptionFruits are edible and it tastes sweet-sour. The interior of the fruit is composed of many pink-red sections of pulp-like tissue, each of which contains a small seed grain. This is usually referred to as "pomegranate seeds", which actually is rather inaccurate.
The plant is a deciduous foliage. Leaves are short stemmed, oblong and lanceolate. Flowers are orange-red, and the fruit is a globose with tough leathery skin. Pomegranate has a calyx shaped like a crown.
Two varieties were identified as : delima putih with white flowers and red fruit pulp; delima merah with red flowers and dark red fruit pulp. Delima putih is more often used for medicinal purpose [201].
Specific actionsFruit peel: astringent; stem bark & root bark: anthelmintic [231].
Frequency in useModerate
Common usesFruits are edible. The root is an anthelmintic and is used to treat tape worm infections. For this reason, once people are obliged to grow Punica granatum in their gardens [201].
Pharmacological effectArils, juice and rinds of Punica granatum fruits and their aqueous and ethyl acetate extracts displayed good antioxidant activity [PMID:16698192].

Dried methanolic extracts were given to rats, followed by CCl4, and the levels of various enzymes were studied. Pretreatment of the rats with the extracts followed by CCl4 causes preservation of catalase, peroxidase and superoxide dismutase to values comparable with control values. Lipid peroxidation was brought back by 54% as compared by control. Histopathological studies of the liver of different groups also support the protective effects exhibited by the MeOH extract of pomegranate peel by restoring the normal hepatic architecture [PMID:12166961].

Antioxidant-rich fractions were extracted from pomegranate (Punica granatum) peels and seeds using ethyl acetate, methanol, and water. The extracts were screened for their potential as antioxidants using various in vitro models. The methanol extract pf pomegranate peel showed the highest antioxidant activity among all of the extract [PMID:11754547].

Fractions rich in flavonoids obtained from the fruits of Punica granatum extract, orally administered to rats at dose of 10 mg kg(-1) day(-1), showed potential antiperoxidative effect [PMID:15752628].

This study assessed the effect of concentrated pomegranate juice consumption on lipid profiles of type II diabetic patients with hyperlipidemia (cholesterol >/= 5.2 mmol/L or triacylglycerol >/= 2.3 mmol/L). It is concluded that concentrated pomegranate juice consumption may modify heart disease risk factors in hyperlipidemic patients, and its inclusion therefore in their diets may be beneficial [PMID:15383223].

The methanolic extract of dried Punica granatum peels showed the presence of a high content of phenolic compounds (44.0%) along with other constituents. This extract was formulated as a 10% (wt/wt) water-soluble gel and was studied for its wound healing property against an excision wound on the skin of Wistar rats. The activity was compared with that of a commercial topical antibacterial applicant.
The results of this study may be extended to different types of wounds so that the formulation could be exploited to develop it as a topical dermatological formulation. High-performance liquid chromatography analysis of the extract showed the presence of gallic acid and catechin as major components [PMID:15298776].
Medical systemIndonesian medicine (Jamu)
Traditional usageThe fruit and its peel is an astringent and used to treat dysentery, diarrhea and excessive leukorrheal/leucorrheal discharge. The fruit peel is used to treat excessive leukorrheal/leucorrheal discharge and thus becomes one of the main ingredients in almost every traditional medicine formula for treating excessive leukorrheal/leucorrheal discharge [201, 222].
Fruit is crushed, mixed with water, honey, gum of Styrax benzoin and boiled. The decoction is used to heal dysentery.
The decoction of flowers is used to treat painful gum.
The root is an anthelmintic and is used to treat tape worm infections. For this reason, once people are obliged to grow P. granatum in their gardens [201, 222].
Formulation1) Excessive leukorrheal/leucorrheal discharge:
 5 grams of fruit peel, 6 grams of fresh Pluchea indica leaves, 5 grams of aerial part of Elephantopus scaber, 1 gram of Quercus infectoria. Mix all ingredients, boil with 110 ml of water. Allow to cool and strain. Drink 100 ml of the decoction once a day for 14 days [231].
ReferencesReference book　

Tips！

[201] K. Heyne, Tumbuhan Berguna Indonesia, Vols. 1-4, 1987. Diedarkan Oleh Koperasi Karyawan Departemen Kehutanan, Jakarta, Indonesia.
Vol. 3, pp 1478-1479.

[207] Badan Penelitian Dan Pengembangan Kesehatan and Departemen Kesehatan, Kesejahteraan Sosial Ri. Vols. 1-5, Inventaris Tanaman Obat Indonesia, Jakarta, Indonesia.
Vol. 1, Part 1 (2000), pp 193-194.

[222] P.T. Eisai Indonesia: Medical Herb Index in Indonesia (Second edition).1995.
p 41.

[231] Soedibyo, Mooryati: Alam Sumber Kesehatan: Manfaat dan Kegunaan (Natural resources for health. Benefits and uses). Balai Pustaka. 1998.
pp 132-133.

Research paper1. Ricci D, Giamperi L, Bucchini A, Fraternale D. Antioxidant activity of Punica granatum fruits. Fitoterapia, 77(4):310-2, 2006. (PMID: 16698192)

2. Sudheesh S, Vijayalakshmi NR. Flavonoids from Punica granatum--potential antiperoxidative agents. Fitoterapia, 76(2):181-6, 2005. (PMID: 15752628)

3. Esmaillzadeh A, Tahbaz F, Gaieni I, Alavi-Majd H, Azadbakht L. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J. Med. Food., 7(3):305-8, 2004. (PMID: 15383223)

4. Murthy KN, Reddy VK, Veigas JM, Murthy UD.Study on wound healing activity of Punica granatum peel. J. Med. Food., 7(2):256-9, 2004. (PMID: 15298776)

5. Chidambara Murthy KN, Jayaprakasha GK, Singh RP.Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models. J. Agric. Food Chem., 14;50(17):4791-5, 2002. (PMID: 12166961)

6. Singh RP, Chidambara Murthy KN, Jayaprakasha GK.Studies on the antioxidant activity of pomegranate (Punica granatum) peel and seed extracts using in vitro models. J. Agric. Food Chem., 2;50(1):81-6, 2002. (PMID: 11754547)
Remarks[DNA sequences] FM886992, FM886993, FM886994, FM886995, FM886996, FM886997, FM886998, FM886999, FM887000, FM887001, FM887002, FM887003, FM887004, FM887005, FM887006, FM887007, FM887008
Last renewal date2024/03/08
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