Crude drug sample data base
※Click on the image to enlarge it.
Scientific information data base
Crude drug name | Indonesian name, English name | Daun beluntas | ||
---|---|---|---|---|
crude drug image |
| |||
Original plant name | Pluchea indica (L.) Less. | |||
Family name | Compositae | |||
Used part | Leaves | |||
Distribution area | It is found from India to southern China, through Indo-China, Thailand, Malaysia, Indonesia, the Philippines, to Australia and the Pacific Islands. In Java, it grows in sunny, dry and stony localities. Many are found near the sea up to 800 m altitude. It can be used as a hedge plant and as an intercrop in teak forests [201, 220]. | |||
Description | The leaves are alternate, simple, ovate to obovate, 2.5-8 cm x 1-5 cm, base attenuate, apex acute or mucronate, margins serrate, obscurely glandular on both surfaces, aromatic when crushed. The plant is an evergreen, slender, erect, much-branched shrub, 1-3 m tall; branches ribbed, woody. Inflorescence consisting of many heads in a hemispherical terminal or axillary corymb or panicle. Fruit a cylindrical achene [220]. | |||
Drug effect | Cooling [231]. | |||
Specific actions | Stomachic, febrifuge, diaphoretic [220, 231]. | |||
Frequency in use | Moderate. | |||
Common uses | Leaves, young tops and inflorescence are consumed raw or cooked in Java as a side-dish to rice, or as a salad [201]. | |||
Pharmacological effect | Studies were carried out to evaluate the influence of the methanol fraction of Pluchea indica Less. root extract, the dual inhibitors (BW 755C and phenidone) and vitamin on both in vivo and in vitro free radical-scavenging activities, CCl(4)-induced lipid peroxidation and the metabolism of arachidonic acid by lipoxygenase. Both BW 755C and phenidone stimulated hydroxyl radical generation compared with the observed inhibitory effects of root extract and vitamin E [PMID: 12112288].. The methanol fraction of P. indica root extract showed significant anti-inflammatory activities on arachidonic acid-, platelet activation factor-and compound 48/80-induced paw oedemas[220]. The methanolic fraction of the root extract exhibits significant hepatoprotective activity against experimentally induced liver damage by CCl4 in rats and mice [220]. Study on the effects of Pluchea indica Less. root extract (PI-E) on locomotor activity and pentobarbital-induced sleep, social isolation-induced aggressive behavior, motor coordination in the rotarod test, pentylenetetrazole-induced convulsion and nociceptive responses in the tail-pinch test were examined in mice.Results suggest that the extract attenuates pathophysiological changes caused by social isolation stress in mice, and that the GABAergic system is partly involved in the action of PI-E on a social isolation-induced decrease in pentobarbital sleep [PMID: 8924905]. The effect of the methanolic fraction of Pluchea indica Less. root extract was evaluated on various models of inflammation and ulcer in vivo to assess the role of P. indica on the 5-lipoxygenase pathway of prostaglandin synthesis. There was significant inhibition of spontaneous as well as compound 48/80-induced histamine release from mast cells. Ulcer studies revealed significant protective action of the fraction on indomethacin, alcohol and indomethacin-alcohol induced ulceration. There was significant decrease of gastric volume and acidity in pylorus ligated rats. Studies also showed a significant protective action of the same on gastric mucosa [PMID: 7680407]. | |||
Medical system | Indonesian medicine (Jamu) | |||
Traditional usage | Leaves are very famous and are eaten raw or steamed to correct foul breath and offensive perspiration odour. Infusion of leaves is used for different kinds of diseases, especially for fever. It is also used against leucorrhea, as a stomachic, a galactogogue, cough medicine. Externally leaves are used in a special bath as an aromatic and stimulant, and also in nerve-strengthening fomentations. Together with Vitex trifolia leaves, the leaves are crushed to make a liniment against weakness after diarrhea. Juice from the crushed leaves are mixed with fennel fruits, bark of Alyxia reinwardtii, turmeric, rhizomes of Curcuma xanthorrhiza, benzoin and used against dysentery. Leaves are crushed and mixed with limestone and used for ulcers and sores. The root is mixed with other ingredients to make a poultice for rheumatic pains [201, 220, 231]. | |||
Formulation | 1) Leucorrhea: 20 pieces of fresh P. indica leaves, 1 whole roots from one Elephantopus scaber herb are pounded, add a little water to make a fine mixture. Squeeze and strain. Drink the juice 1/4 cup once a day for 14 days. Best results can be obtained by washing the vagina with decoction of Piper betle leaves [231]. 2) Rheumatic pain, low back pain: 5 grams of roots of P. indica, 7 grams of rhizomes of Kaempferia galanga, 6 grams of Curcuma xanthorrhiza, 6 grams of Curcuma domestica are mixed with 120 ml of water and pounded. Squeeze, strain, drink the juice 100 ml once a day for 14 days. It is followed by drinking the juice 100 ml every 2 days [231]. | |||
References | Reference book Tips! | [201] K. Heyne, Tumbuhan Berguna Indonesia, Vols. 1-4, 1987. Diedarkan Oleh Koperasi Karyawan Departemen Kehutanan, Jakarta, Indonesia. Vol. 3, p 1832. [220] van Valkenburg, J.L.C.H. and Bunyapraphatsara, N. (editors). Plant Resources of South-East Asia No. 12 (2). Medicinal and posionous plants 2. Prosea Foundation, Bogor, Indonesia, 2002. pp 441-443. [222] P.T. Eisai Indonesia: Medical Herb Index in Indonesia (Second edition).1995. pp 225-226. [231] Soedibyo, Mooryati: Alam Sumber Kesehatan: Manfaat dan Kegunaan (Natural resources for health. Benefits and uses). Balai Pustaka. 1998. pp 82-83. | ||
Research paper | 1. Sen T, Dhara AK, Bhattacharjee S, Pal S, Nag Chaudhuri AK. Antioxidant activity of the methanol fraction of Pluchea indica root extract. Phytother Res. 16(4):331-5, 2002. (PMID: 12112288) 2. Thongpraditchote S, Matsumoto K, Temsiririrkkul R, Tohda M, Murakami Y, Watanabe H. Neuropharmacological actions of Pluchea indica Less. root extract in socially isolated mice. Biol Pharm Bull. 19(3):379-83, 1996. (PMID: 8924905) 3. Sen T, Ghosh TK, Chaudhuri AK. Studies on the mechanism of anti-inflammatory and anti-ulcer activity of Pluchea indica--probable involvement of 5-lipooxygenase pathway. Life Sci. 52(8):737-43, 1993. (PMID: 7680407) | |||
Remarks | The significant activity of the methanol fraction of the root extracts in many inflammation and anti-ulcer models needs further research [220]. | |||
Last renewal date | 2024/02/29 |